HitPredict

Interactor 1: RAB6 (O18334)
Ras-related protein Rab6 (Protein warthog)
Gene: RAB6

Interactor 2: O61444 (O61444)
mitogen-activated protein kinase kinase (EC 2.7.12.2)
Gene: Mkk4

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.709

Property	Details
Experiments	25453831, 15710747
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 208 Dm			1 424
+	At
		221736 RAA1E_ARATH (1-207): 6.36e-86: 254: 32.56		KIN10_ARATH (107-424): 3.04e-125: 373: 19.69
+	Hs
		625461 RB11B_HUMAN (1-207): 2.19e-87: 258: 30.56		CDK2_HUMAN (119-398): 7.4e-119: 349: 19.74
+	Hs
		894729 RAB8A_HUMAN (10-203): 1.57e-87: 258: 40.51		STK4_HUMAN (95-415): 3.5e-113: 342: 28.17
+	Hs
		894835 RAB8A_HUMAN (10-203): 1.57e-87: 258: 40.51		STK24_HUMAN (99-410): 8.49e-99: 303: 29.71
+	Hs
		914500 RB11A_HUMAN (1-207): 1.84e-87: 258: 30.84		STK24_HUMAN (99-410): 8.49e-99: 303: 29.71
+	Zm
		8047 B4F7V6_MAIZE (3-206): 6.12e-48: 157: 40.20		A0A1D6EK73_MAIZE (105-418): 4.58e-122: 365: 18.73
+	Hs
		153105 RAB5C_HUMAN (7-188): 3.48e-51: 166: 41.12		MP2K7_HUMAN (37-419): 7.54e-118: 351: 42.38
+	Hs
		625247 RAB5C_HUMAN (7-188): 3.48e-51: 166: 41.12		CDK2_HUMAN (119-398): 7.4e-119: 349: 19.74
+	Hs
		844490 RAB5C_HUMAN (7-188): 3.48e-51: 166: 41.12		MP2K1_HUMAN (67-415): 1.2e-94: 291: 32.17