Protein: TMTC3
Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3)

Gene: TMTC3
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q6ZXV5

Gene Ontology (top 5):
GO:0000030 - mannosyltransferase activity
GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0016020 - membrane
GO:0034976 - response to endoplasmic reticulum stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1244872

NCEH1
Neutral cholesterol ester hydrolase 1

3

1

High-throughput

0.662

High

749783

CADH5
Cadherin-5

2

9

High-throughput

0.628

High

1257555

SCN3B
Sodium channel regulatory subunit beta-3

2

2

High-throughput

0.628

High

535223

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.618

High

979871

H4
Histone H4

1

2

High-throughput

0.618

High

988470

RAC1
Ras-related C3 botulinum toxin substrate 1

1

3

High-throughput

0.618

High

1036211

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

2

High-throughput

0.618

High

1098426

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.618

High

1192247

ZACN
Ligand-gated cation channel ZACN

3

8

High-throughput

0.609

High

1257529

5HT3C
5-hydroxytryptamine receptor 3C

3

7

High-throughput

0.609

High

1257562

FBX2
F-box only protein 2

2

2

High-throughput

0.601

High

855337

5HT3A
5-hydroxytryptamine receptor 3A

2

7

High-throughput

0.574

High

1057553

ACHD
Acetylcholine receptor subunit delta

2

5

High-throughput

0.574

High

1257518

LYZL2
Lysozyme-like protein 2

2

1

High-throughput

0.574

High

126663

RHOD
Rho-related GTP-binding protein RhoD

1

7

High-throughput

0.553

High

910105

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.553

High

962192

RHOA
Transforming protein RhoA

1

4

High-throughput

0.553

High

978105

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.553

High

1257547

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.553

High

1257549

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.553

High

607942

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

5

High-throughput

0.536

High

698801

CALX
Calnexin

1

10

High-throughput

0.536

High

723235

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

5

High-throughput

0.536

High

851149

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

5

High-throughput

0.536

High

1257534

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1257538

CREL1
Protein disulfide isomerase CRELD1

1

6

High-throughput

0.536

High

1257550

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

1257563

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

1

3

High-throughput

0.536

High

1257568

LAMC3
Laminin subunit gamma-3

1

5

High-throughput

0.536

High

1257539

CALR3
Calreticulin-3

2

10

High-throughput

0.533

High

286383

DAB1
Disabled homolog 1

1

1

High-throughput

0.523

High

1257545

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

679196

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.489

High

731866

CEAM8
Cell adhesion molecule CEACAM8

1

3

High-throughput

0.489

High

1117000

LAMB3
Laminin subunit beta-3

1

6

High-throughput

0.489

High

1257520

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1257533

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.489

High

1257566

PCDB7
Protocadherin beta-7

1

11

High-throughput

0.489

High

1257567

PCDB1
Protocadherin beta-1

1

10

High-throughput

0.489

High

140973

NOP56
Nucleolar protein 56

1

5

High-throughput

0.479

High

229741

CALU
Calumenin

1

7

High-throughput

0.479

High

242078

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

404152

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

414078

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

566726

PDIA4
Protein disulfide-isomerase A4

1

19

High-throughput

0.479

High

930326

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

5

High-throughput

0.479

High

951225

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

967472

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.479

High

1163779

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

3

High-throughput

0.479

High

1179100

TECT1
Tectonic-1

1

3

High-throughput

0.479

High

1252098

SYNE3
Nesprin-3

1

3

High-throughput

0.479

High

1257521

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

1257526

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

1257532

AKAP1
A-kinase anchor protein 1, mitochondrial

1

8

High-throughput

0.479

High

1257535

LRC59
Leucine-rich repeat-containing protein 59

1

6

High-throughput

0.479

High

1257536

PLD4
5'-3' exonuclease PLD4

1

5

High-throughput

0.479

High

1257557

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.479

High

1257558

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.479

High

1257564

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

5

High-throughput

0.479

High

1247926

ANR12
Ankyrin repeat domain-containing protein 12

1

7

High-throughput

0.470

High

1257552

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

170833

CLGN
Calmegin

1

10

High-throughput

0.445

High

898491

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.445

High

1053022

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.445

High

1181388

P3H1
Prolyl 3-hydroxylase 1

1

3

High-throughput

0.445

High

1257543

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.445

High

1257546

TOR3A
Torsin-3A

1

3

High-throughput

0.445

High

218364

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

269455

KI21B
Kinesin-like protein KIF21B

1

5

High-throughput

0.437

High

385884

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.437

High

588987

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

680719

CATS
Cathepsin S

1

2

High-throughput

0.437

High

695774

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

768493

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1004744

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1005542

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

1

5

High-throughput

0.437

High

1238720

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1248962

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1250160

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1254348

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1257517

KI21A
Kinesin-like protein KIF21A

1

5

High-throughput

0.437

High

1257519

PLD3
5'-3' exonuclease PLD3

1

5

High-throughput

0.437

High

1257522

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.437

High

1257540

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

20

High-throughput

0.437

High

1257542

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1257548

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

1257553

FBX6
F-box only protein 6

1

2

High-throughput

0.437

High

1257554

T106B
Transmembrane protein 106B

1

3

High-throughput

0.437

High

1257556

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

1257559

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.437

High

248896

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

1238992

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.426

High

1257560

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.426

High

51442

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

11

High-throughput

0.407

High

466925

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.407

High

679360

DNJB2
DnaJ homolog subfamily B member 2

1

20

High-throughput

0.407

High

867637

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.407

High

1180738

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

2

High-throughput

0.407

High

1257524

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.407

High

1257525

FXL16
F-box/LRR-repeat protein 16

1

7

High-throughput

0.407

High

1257531

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.407

High

1257537

SAAL1
Protein SAAL1

1

2

High-throughput

0.407

High

1257544

DJC25
DnaJ homolog subfamily C member 25

1

20

High-throughput

0.407

High

1257561

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

7

High-throughput

0.407

High

1257565

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

3

High-throughput

0.407

High

1030791

DEF5
Defensin alpha 5

3

0

High-throughput

0.345

High

230705

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

506863

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

1133838

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

0

High-throughput

0.279

Low

1248819

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

1257523

SYNE4
Nesprin-4

1

0

High-throughput

0.249

Low

1257527

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.249

Low

1257528

FSIP1
Fibrous sheath-interacting protein 1

1

0

High-throughput

0.249

Low

1257530

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.249

Low

1257551

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.249

Low

222295

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

1257541

FUZZY
Protein fuzzy homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025