Protein: CDC27
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)

Gene: CDC27
Organism: Homo sapiens
Interactions: 231
UniProt ID: P30260

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005737 - cytoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718554

CDC16
Cell division cycle protein 16 homolog

25

17

Small-scale

0.990

High

718652

APC7
Anaphase-promoting complex subunit 7

21

18

Small-scale

0.987

High

718651

CDC23
Cell division cycle protein 23 homolog

20

17

Small-scale

0.987

High

718653

APC5
Anaphase-promoting complex subunit 5

20

10

Small-scale

0.986

High

718662

APC10
Anaphase-promoting complex subunit 10

11

15

Small-scale

0.973

High

718597

CDC26
Anaphase-promoting complex subunit CDC26

11

5

Small-scale

0.971

High

718607

APC16
Anaphase-promoting complex subunit 16

9

4

Small-scale

0.968

High

718503

CDC27
Cell division cycle protein 27 homolog

7

17

Small-scale

0.951

High

718619

APC13
Anaphase-promoting complex subunit 13

5

5

Small-scale

0.916

High

718529

APC15
Anaphase-promoting complex subunit 15

3

7

Small-scale

0.861

High

718552

CDC20
Cell division cycle protein 20 homolog

62

20

Small-scale

0.772

High

718661

FZR1
Fizzy-related protein homolog

36

20

Small-scale

0.770

High

718654

APC4
Anaphase-promoting complex subunit 4

33

9

Small-scale

0.769

High

718556

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

29

7

Small-scale

0.768

High

251713

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

25

17

Small-scale

0.767

High

718655

ANC2
Anaphase-promoting complex subunit 2

17

18

Small-scale

0.761

High

718623

APC1
Anaphase-promoting complex subunit 1

14

9

Small-scale

0.757

High

718658

FBX5
F-box only protein 5

8

7

Small-scale

0.750

High

224230

BUB3
Mitotic checkpoint protein BUB3

8

9

Small-scale

0.747

High

718640

APC11
Anaphase-promoting complex subunit 11

8

10

Small-scale

0.740

High

573758

CCNB1
G2/mitotic-specific cyclin-B1

7

8

Small-scale

0.738

High

718522

NEK2
Serine/threonine-protein kinase Nek2

6

11

Small-scale

0.730

High

718575

UBE2S
Ubiquitin-conjugating enzyme E2 S

5

7

Small-scale

0.704

High

555896

CADH1
Cadherin-1

5

6

Small-scale

0.702

High

718517

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.691

High

351273

TTLL1
Polyglutamylase complex subunit TTLL1

4

2

High-throughput

0.691

High

718604

SH3K1
SH3 domain-containing kinase-binding protein 1

4

11

High-throughput

0.691

High

718526

PLK1
Serine/threonine-protein kinase PLK1

4

9

Small-scale

0.686

High

353793

PTTG1
Securin

5

0

Small-scale

0.680

High

718565

MDC1
Mediator of DNA damage checkpoint protein 1

3

17

Small-scale

0.678

High

292813

GRAP2
GRB2-related adapter protein 2

3

12

High-throughput

0.667

High

718505

RIR2
Ribonucleoside-diphosphate reductase subunit M2

3

2

High-throughput

0.667

High

718525

PPP5
Serine/threonine-protein phosphatase 5

1

7

Small-scale

0.647

High

718507

TTK
Dual specificity protein kinase TTK

3

9

Small-scale

0.640

High

718558

SQSTM
Sequestosome-1

3

4

High-throughput

0.640

High

718578

ANO6
Anoctamin-6

2

3

High-throughput

0.628

High

718585

RN19B
E3 ubiquitin-protein ligase RNF19B

2

14

High-throughput

0.628

High

718593

KIF2B
Kinesin-like protein KIF2B

2

6

High-throughput

0.628

High

718633

ZN408
Zinc finger protein 408

2

3

High-throughput

0.628

High

315175

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.618

High

375218

RASK
GTPase KRas

1

3

High-throughput

0.618

High

536578

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.618

High

718535

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.618

High

718536

H4
Histone H4

1

6

High-throughput

0.618

High

718539

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

Small-scale

0.618

High

718592

CUL9
Cullin-9

1

6

Small-scale

0.618

High

718561

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

6

High-throughput

0.611

High

718573

SMAD2
Mothers against decapentaplegic homolog 2

2

6

Small-scale

0.611

High

377079

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

1

High-throughput

0.609

High

718631

MAGIX
PDZ domain-containing protein MAGIX

3

6

High-throughput

0.609

High

718559

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

Small-scale

0.607

High

442609

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.606

High

718584

CP087
UPF0547 protein C16orf87

3

4

High-throughput

0.604

High

718530

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.599

High

718614

DCR1C
Protein artemis

2

0

High-throughput

0.585

High

169969

AURKA
Aurora kinase A

2

6

Small-scale

0.584

High

240849

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.584

High

259503

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

445750

ENOA
Alpha-enolase

2

2

Small-scale

0.584

High

629066

CCNA2
Cyclin-A2

2

8

Small-scale

0.584

High

718540

H31
Histone H3.1

2

7

High-throughput

0.584

High

718550

FOXM1
Forkhead box protein M1

2

2

Small-scale

0.584

High

718557

SKP2
S-phase kinase-associated protein 2

2

2

Small-scale

0.584

High

718589

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

2

7

Small-scale

0.584

High

718594

SIR6
NAD-dependent protein deacylase sirtuin-6

2

4

Small-scale

0.584

High

718603

CBP
CREB-binding protein

2

17

Small-scale

0.584

High

718609

AURKB
Aurora kinase B

2

6

Small-scale

0.584

High

718649

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

7

Small-scale

0.584

High

718581

Q5T8C6
Cell division cycle 16

1

17

High-throughput

0.575

High

395563

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

718548

HSF2
Heat shock factor protein 2

1

3

Small-scale

0.561

High

718627

CUED2
CUE domain-containing protein 2

2

0

Small-scale

0.559

High

219699

FOXO3
Forkhead box protein O3

1

4

High-throughput

0.554

High

718600

ELMO1
Engulfment and cell motility protein 1

1

1

Small-scale

0.552

High

642198

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.549

High

718544

ID2
DNA-binding protein inhibitor ID-2

1

0

Small-scale

0.537

High

133086

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

455704

H10
Histone H1.0

1

2

High-throughput

0.536

High

501918

H2AZ
Histone H2A.Z

1

4

High-throughput

0.536

High

601572

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

664647

CCND1
G1/S-specific cyclin-D1

1

9

Small-scale

0.536

High

718521

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.536

High

718538

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

718549

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.536

High

718560

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

718567

NUMA1
Nuclear mitotic apparatus protein 1

1

3

High-throughput

0.536

High

718576

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.536

High

718582

RSBN1
Lysine-specific demethylase 9

1

1

High-throughput

0.536

High

718602

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

718605

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.536

High

718615

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

718620

FOXP3
Forkhead box protein P3

1

3

High-throughput

0.536

High

718621

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.536

High

718624

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

718630

RABE2
Rab GTPase-binding effector protein 2

1

4

High-throughput

0.536

High

718648

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

718656

PO2F3
POU domain, class 2, transcription factor 3

1

2

High-throughput

0.536

High

718545

H11
Histone H1.1

1

4

High-throughput

0.515

High

718591

CC125
Coiled-coil domain-containing protein 125

1

1

High-throughput

0.515

High

571751

FPPS
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.513

High

718518

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

718572

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

718596

MCPH1
Microcephalin

1

0

Small-scale

0.513

High

718599

ZN526
Zinc finger protein 526

1

0

High-throughput

0.513

High

718617

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.513

High

718642

CFA97
Cilia- and flagella-associated protein 97

1

3

High-throughput

0.506

High

507573

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

718508

CTNB1
Catenin beta-1

1

6

Small-scale

0.501

High

718531

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

2

Small-scale

0.501

High

718667

LTOR2
Ragulator complex protein LAMTOR2

1

2

High-throughput

0.489

High

718608

CDCA5
Sororin

1

0

Small-scale

0.479

High

131132

CLIC1
Chloride intracellular channel protein 1

1

1

Small-scale

0.479

High

172495

XPO1
Exportin-1

1

17

High-throughput

0.479

High

221237

DCX
Neuronal migration protein doublecortin

1

2

Small-scale

0.479

High

326926

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.479

High

342118

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

345418

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

362177

ABL1
Tyrosine-protein kinase ABL1

1

4

High-throughput

0.479

High

371265

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

411431

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

440396

FYN
Tyrosine-protein kinase Fyn

1

4

High-throughput

0.479

High

479772

GSTP1
Glutathione S-transferase P

1

3

Small-scale

0.479

High

519774

ANDR
Androgen receptor

1

19

Small-scale

0.479

High

553128

KCRB
Creatine kinase B-type

1

2

Small-scale

0.479

High

553709

ANXA3
Annexin A3

1

3

Small-scale

0.479

High

578395

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.479

High

587996

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

593924

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.479

High

606291

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

616141

PGAM1
Phosphoglycerate mutase 1

1

1

Small-scale

0.479

High

623130

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

Small-scale

0.479

High

639674

TAF1
Transcription initiation factor TFIID subunit 1

1

19

Small-scale

0.479

High

674085

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

694706

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

699605

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.479

High

700560

PSA5
Proteasome subunit alpha type-5

1

5

Small-scale

0.479

High

718504

WEE1
Wee1-like protein kinase

1

11

High-throughput

0.479

High

718506

H2B1B
Histone H2B type 1-B

1

6

Small-scale

0.479

High

718509

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

718510

HXD13
Homeobox protein Hox-D13

1

2

Small-scale

0.479

High

718512

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

718514

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

718515

GATA4
Transcription factor GATA-4

1

6

High-throughput

0.479

High

718516

ATRX
Transcriptional regulator ATRX

1

10

Small-scale

0.479

High

718519

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

718520

MXI1
Max-interacting protein 1

1

3

Small-scale

0.479

High

718523

NEK3
Serine/threonine-protein kinase Nek3

1

13

High-throughput

0.479

High

718524

NUP98
Nuclear pore complex protein Nup98-Nup96

1

2

Small-scale

0.479

High

718527

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

718532

WDR5
WD repeat-containing protein 5

1

7

Small-scale

0.479

High

718533

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

718537

GRB2
Growth factor receptor-bound protein 2

1

9

High-throughput

0.479

High

718541

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

718542

H33
Histone H3.3

1

7

High-throughput

0.479

High

718543

E2F1
Transcription factor E2F1

1

1

Small-scale

0.479

High

718546

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

2

Small-scale

0.479

High

718547

KMT2A
Histone-lysine N-methyltransferase 2A

1

11

Small-scale

0.479

High

718551

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

718553

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

718555

FADD
FAS-associated death domain protein

1

1

Small-scale

0.479

High

718562

TFDP1
Transcription factor Dp-1

1

1

Small-scale

0.479

High

718566

IMB1
Importin subunit beta-1

1

2

High-throughput

0.479

High

718569

BRD3
Bromodomain-containing protein 3

1

15

High-throughput

0.479

High

718570

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

4

Small-scale

0.479

High

718571

RBBP5
Retinoblastoma-binding protein 5

1

8

Small-scale

0.479

High

718574

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.479

High

718577

FBX43
F-box only protein 43

1

7

Small-scale

0.479

High

718583

DAB2P
Disabled homolog 2-interacting protein

1

1

Small-scale

0.479

High

718586

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

718587

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.479

High

718588

SPERI
Speriolin

1

3

Small-scale

0.479

High

718590

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

Small-scale

0.479

High

718595

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

12

Small-scale

0.479

High

718598

KI18A
Kinesin-like protein KIF18A

1

8

Small-scale

0.479

High

718601

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

718611

ELMO2
Engulfment and cell motility protein 2

1

1

Small-scale

0.479

High

718612

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

718613

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

718616

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

718622

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

718628

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

11

High-throughput

0.479

High

718629

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

718632

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

718634

PKHA5
Pleckstrin homology domain-containing family A member 5

1

12

Small-scale

0.479

High

718635

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

5

High-throughput

0.479

High

718636

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

718637

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

7

Small-scale

0.479

High

718639

HXC10
Homeobox protein Hox-C10

1

1

Small-scale

0.479

High

718641

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

718643

HECW2
E3 ubiquitin-protein ligase HECW2

1

9

High-throughput

0.479

High

718644

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

Small-scale

0.479

High

718645

REV1
DNA repair protein REV1

1

1

Small-scale

0.479

High

718646

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

718650

XPO7
Exportin-7

1

15

High-throughput

0.479

High

718659

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

Small-scale

0.479

High

718663

TRI33
E3 ubiquitin-protein ligase TRIM33

1

12

Small-scale

0.479

High

718664

PHF8
Histone lysine demethylase PHF8

1

6

Small-scale

0.479

High

718665

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

718666

NINL
Ninein-like protein

1

2

Small-scale

0.479

High

718668

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

718669

TACC3
Transforming acidic coiled-coil-containing protein 3

1

11

Small-scale

0.479

High

718671

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

2

Small-scale

0.479

High

718606

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.460

High

718626

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.460

High

284288

GEMI
Geminin

1

0

Small-scale

0.458

High

550868

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

599547

STMN1
Stathmin

1

0

Small-scale

0.458

High

628711

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

718511

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

718513

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.458

High

718528

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

718534

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

718563

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

718564

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

718568

MD2BP
MAD2L1-binding protein

1

0

Small-scale

0.458

High

718579

BOREA
Borealin

1

0

Small-scale

0.458

High

718618

PYM1
Partner of Y14 and mago

1

0

Small-scale

0.458

High

718625

EPN3
Epsin-3

1

0

High-throughput

0.458

High

718657

NUDT5
ADP-sugar pyrophosphatase

1

0

Small-scale

0.458

High

718660

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.458

High

171403

S27A2
Long-chain fatty acid transport protein 2

1

3

High-throughput

0.445

High

718580

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

642649

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

718670

EMIL1
EMILIN-1

1

3

Small-scale

0.437

High

718610

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

718647

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.279

Low

718638

GKN1
Gastrokine-1

1

0

High-throughput

0.251

Low

49932

LNP1
Leukemia NUP98 fusion partner 1

1

0

Small-scale

0.249

Low

561023

CCL4
C-C motif chemokine 4

1

0

Small-scale

0.249

Low

437630

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025