HitPredict

Interactor 1: ALX4 (O35137)
Homeobox protein aristaless-like 4 (ALX-4)
Gene: ALX4

Interactor 2: Q8VD35 (Q8VD35)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 399 Mm			1 289
+	Mm
		192303 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		Q8R0B5_MOUSE (1-289): 4.77e-71: 222: 96.63
+	Mm
		192281 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		PAX3_MOUSE (12-275): 1.39e-35: 135: 25.09
+	Mm
		192275 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		ALX4_MOUSE (11-237): 8.88e-34: 128: 23.58
+	Mm
		192277 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		LMX1B_MOUSE (1-229): 7.75e-34: 128: 17.92
+	Hs
		1077278 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX1_HUMAN (2-197): 2.59e-37: 136: 28.14
+	Hs
		1328470 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX4_HUMAN (14-237): 4.43e-33: 126: 23.45
+	Bt
		1187205 RAX2_BOVIN (199-328): 4.27e-42: 148: 41.22		CRX_BOVIN (1-289): 2.1e-39: 141: 46.58
+	Hs
		197795 RAX2_HUMAN (197-327): 3.97e-39: 140: 42.42		CRX_HUMAN (1-289): 5.69e-41: 145: 46.91
+	Hs
		656400 PIT1_HUMAN (2-267): 2.75e-39: 143: 13.03		PITX1_HUMAN (16-259): 8.79e-35: 129: 26.42
+	Hs
		678782 HXD3_HUMAN (8-376): 4.7e-39: 146: 17.82		ALX4_HUMAN (14-237): 4.43e-33: 126: 23.45
+	Hs
		174008 SHOX_HUMAN (191-397): 2.79e-37: 138: 28.50		SHOX_HUMAN (22-103): 2.86e-34: 127: 51.22
+	Hs
		641325 PAX6_HUMAN (123-379): 1.66e-32: 128: 24.81		PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39
+	Mm
		192276 RX_MOUSE (122-395): 1.23e-33: 130: 29.08		ALX4_MOUSE (11-237): 8.88e-34: 128: 23.58
+	Mm
		936459 PITX1_MOUSE (138-393): 5.24e-33: 127: 27.57		PITX1_MOUSE (14-259): 5.43e-35: 130: 27.02
+	Hs
		941950 PITX1_HUMAN (138-393): 1.88e-33: 128: 28.04		PITX2_HUMAN (4-262): 1.11e-34: 129: 23.49
+	Mm
		192280 HXD12_MOUSE (22-265): 5.73e-33: 126: 21.72		ALX4_MOUSE (11-237): 8.88e-34: 128: 23.58
+	Hs
		641609 PAX6_HUMAN (123-379): 1.66e-32: 128: 24.81		RX_HUMAN (36-137): 3.46e-16: 79.3: 48.04