Protein: SC22A
Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2)

Gene: SC22A, SEC22A
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q96IW7

Gene Ontology (top 5):
GO:0005484 - SNAP receptor activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1087241

STX4
Syntaxin-4

3

20

High-throughput

0.675

High

1379865

FATE1
Fetal and adult testis-expressed transcript protein

3

1

High-throughput

0.675

High

1369295

EDA
Ectodysplasin-A

4

0

High-throughput

0.668

High

283334

ERLN1
Erlin-1

3

0

High-throughput

0.646

High

548091

PSPC
Surfactant protein C

3

0

High-throughput

0.646

High

1289270

DTX2
Probable E3 ubiquitin-protein ligase DTX2

4

1

High-throughput

0.642

High

292719

RENR
Renin receptor

2

1

High-throughput

0.606

High

746216

STX2
Syntaxin-2

2

20

High-throughput

0.606

High

898254

R144A
E3 ubiquitin-protein ligase RNF144A

2

1

High-throughput

0.606

High

1159623

STX1A
Syntaxin-1A

2

20

High-throughput

0.606

High

1252074

RN19B
E3 ubiquitin-protein ligase RNF19B

2

3

High-throughput

0.606

High

1384333

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.606

High

1394438

MGST2
Microsomal glutathione S-transferase 2

2

2

High-throughput

0.606

High

1394443

TMED9
Transmembrane emp24 domain-containing protein 9

2

5

High-throughput

0.606

High

1394444

T106C
Transmembrane protein 106C

2

1

High-throughput

0.606

High

1394448

ELOV4
Very long chain fatty acid elongase 4

2

3

High-throughput

0.606

High

1394461

SAR1A
Small COPII coat GTPase SAR1A

2

13

High-throughput

0.606

High

161365

PTGES
Prostaglandin E synthase

2

0

High-throughput

0.580

High

1092080

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

1212759

ZFY27
Protrudin

2

0

High-throughput

0.580

High

1291460

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.580

High

1310697

TRI59
Tripartite motif-containing protein 59

2

0

High-throughput

0.580

High

1327932

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1357179

TM174
Transmembrane protein 174

2

0

High-throughput

0.580

High

1384211

LDAF1
Lipid droplet assembly factor 1

2

0

High-throughput

0.580

High

142105

PEX12
Peroxisome assembly protein 12

2

1

High-throughput

0.553

High

188965

TMPS2
Transmembrane protease serine 2

2

2

High-throughput

0.553

High

258662

G37L1
G-protein coupled receptor 37-like 1

2

2

High-throughput

0.553

High

335259

CXB5
Gap junction beta-5 protein

2

9

High-throughput

0.553

High

337297

CXB6
Gap junction beta-6 protein

2

9

High-throughput

0.553

High

456002

ASGR2
Asialoglycoprotein receptor 2

2

7

High-throughput

0.553

High

766768

PHB1
Prohibitin 1

2

2

High-throughput

0.553

High

770902

OPRM
Mu-type opioid receptor

2

2

High-throughput

0.553

High

851084

LPAR6
Lysophosphatidic acid receptor 6

2

3

High-throughput

0.553

High

883437

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

1

High-throughput

0.553

High

1109015

AQP6
Aquaporin-6

2

4

High-throughput

0.553

High

1177864

CL12B
C-type lectin domain family 12 member B

2

7

High-throughput

0.553

High

1200544

CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1

2

1

High-throughput

0.553

High

1207586

F209A
Protein FAM209A

2

1

High-throughput

0.553

High

1242810

RNK
Ribonuclease kappa

2

1

High-throughput

0.553

High

1307730

CLC10
C-type lectin domain family 10 member A

2

6

High-throughput

0.553

High

1333950

DHB11
Estradiol 17-beta-dehydrogenase 11

2

3

High-throughput

0.553

High

1347192

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

2

High-throughput

0.553

High

1347765

STML3
Stomatin-like protein 3

2

2

High-throughput

0.553

High

1349093

F174A
Membrane protein FAM174A

2

1

High-throughput

0.553

High

1393273

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

2

High-throughput

0.553

High

1394431

M4A14
Membrane-spanning 4-domains subfamily A member 14

2

2

High-throughput

0.553

High

1394432

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

2

2

High-throughput

0.553

High

1394435

TLCD4
TLC domain-containing protein 4

2

1

High-throughput

0.553

High

1394441

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

1

High-throughput

0.553

High

1394445

CLC7A
C-type lectin domain family 7 member A

2

6

High-throughput

0.553

High

1394446

CABP8
Calcium-binding protein 8

2

1

High-throughput

0.553

High

1394450

MFF
Mitochondrial fission factor

2

1

High-throughput

0.553

High

1394457

S39A2
Zinc transporter ZIP2

2

4

High-throughput

0.553

High

1394459

S35C2
Solute carrier family 35 member C2

2

1

High-throughput

0.553

High

1394460

DBLOH
Diablo IAP-binding mitochondrial protein

2

1

High-throughput

0.553

High

1394463

SCN3B
Sodium channel regulatory subunit beta-3

2

2

High-throughput

0.553

High

1394465

CLM8
CMRF35-like molecule 8

2

1

High-throughput

0.553

High

1394466

CLC2D
C-type lectin domain family 2 member D

2

7

High-throughput

0.553

High

1394467

CLC4K
C-type lectin domain family 4 member K

2

5

High-throughput

0.553

High

1394468

TFR2
Transferrin receptor protein 2

2

1

High-throughput

0.553

High

1394440

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.549

High

699009

CALX
Calnexin

1

2

High-throughput

0.536

High

888958

TMEDA
Transmembrane emp24 domain-containing protein 10

1

5

High-throughput

0.536

High

1394454

GORS2
Golgi reassembly-stacking protein 2

1

2

High-throughput

0.536

High

1380469

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

570958

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.489

High

1097866

STX5
Syntaxin-5

1

20

Small-scale

0.479

High

1394456

RAB18
Ras-related protein Rab-18

1

6

Small-scale

0.479

High

926824

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.460

High

255856

USO1
General vesicular transport factor p115

1

5

Small-scale

0.445

High

564214

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

386103

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.439

High

1134150

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.439

High

551201

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.437

High

587772

DESP
Desmoplakin

1

1

High-throughput

0.437

High

1004971

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1026509

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.437

High

1334510

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1394452

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1394439

SC6A7
Sodium-dependent proline transporter

1

1

High-throughput

0.407

High

640685

MSRE
Macrophage scavenger receptor types I and II

4

0

High-throughput

0.364

High

1394442

TMM79
Transmembrane protein 79

4

0

High-throughput

0.364

High

212471

SPIT2
Kunitz-type protease inhibitor 2

2

0

High-throughput

0.318

High

220192

TNF14
Tumor necrosis factor ligand superfamily member 14

2

0

High-throughput

0.316

High

407123

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.316

High

483843

CD7
T-cell antigen CD7

2

0

High-throughput

0.316

High

605947

TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase

2

0

High-throughput

0.316

High

636498

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

2

0

High-throughput

0.316

High

748804

ICAM3
Intercellular adhesion molecule 3

2

0

High-throughput

0.316

High

951948

SYCY2
Syncytin-2

2

0

High-throughput

0.316

High

993083

KCNJ2
Inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

1050868

DCE2
Glutamate decarboxylase 2

2

0

High-throughput

0.316

High

1102444

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1155090

UT2
Urea transporter 2

2

0

High-throughput

0.316

High

1195258

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.316

High

1204204

RIPL1
RILP-like protein 1

2

0

High-throughput

0.316

High

1213677

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

2

0

High-throughput

0.316

High

1242533

GGT6
Glutathione hydrolase 6

2

0

High-throughput

0.316

High

1243005

TMM71
Transmembrane protein 71

2

0

High-throughput

0.316

High

1244991

TRAT1
T-cell receptor-associated transmembrane adapter 1

2

0

High-throughput

0.316

High

1248416

CP054
Transmembrane protein C16orf54

2

0

High-throughput

0.316

High

1294654

AGRG3
Adhesion G protein-coupled receptor G3

2

0

High-throughput

0.316

High

1315187

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

0

High-throughput

0.316

High

1322567

LSME2
Leucine-rich single-pass membrane protein 2

2

0

High-throughput

0.316

High

1324844

LRC25
Leucine-rich repeat-containing protein 25

2

0

High-throughput

0.316

High

1351248

GRP4
RAS guanyl-releasing protein 4

2

0

High-throughput

0.316

High

1351518

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.316

High

1382487

T53I1
Tumor protein p53-inducible nuclear protein 1

2

0

High-throughput

0.316

High

1383960

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

1386859

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1393243

GRM2B
GRAM domain-containing protein 2B

2

0

High-throughput

0.316

High

1394433

SUSD3
Sushi domain-containing protein 3

2

0

High-throughput

0.316

High

1394434

FIMP
Fertilization-influencing membrane protein

2

0

High-throughput

0.316

High

1394436

TM237
Transmembrane protein 237

2

0

High-throughput

0.316

High

1394447

SMIM3
Small integral membrane protein 3

2

0

High-throughput

0.316

High

1394449

MCLN1
Mucolipin-1

2

0

High-throughput

0.316

High

1394451

STMN4
Stathmin-4

2

0

High-throughput

0.316

High

1394453

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.316

High

1394458

SPAG4
Sperm-associated antigen 4 protein

2

0

High-throughput

0.316

High

1394462

SDHF2
Succinate dehydrogenase assembly factor 2, mitochondrial

2

0

High-throughput

0.316

High

1394464

HCST
Hematopoietic cell signal transducer

2

0

High-throughput

0.316

High

1394469

MNAR1
Major intrinsically disordered Notch2-binding receptor 1

2

0

High-throughput

0.316

High

1323878

SYNE4
Nesprin-4

1

0

High-throughput

0.299

High

1394437

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

1394455

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.279

Low

1338037

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025