HitPredict

Interactor 1: SEM6A (O35464)
Semaphorin-6A (Semaphorin Q) (Sema Q) (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)
Gene: Sema6a

Interactor 2: PLXA4 (Q80UG2)
Plexin-A4
Gene: Plxna4

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26633812, 20606624
Identification Methods	pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PSI~Sema, PSI~TIG, PSI~TIG_2, PSI~TIG_plexin, Sema~Sema, Sema~TIG, Sema~TIG_plexin
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0071526 - semaphorin-plexin signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1031 Mm			1 1893
+	Mm
		1176226 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA4_MOUSE (1-1893): 0: 2673: 100.00
+	Mm
		192795 SEM6A_MOUSE (1-1031): 0: 985: 100.00		PLXA2_MOUSE (9-1893): 0: 2458: 66.86
+	Mm
		192794 SEM6A_MOUSE (1-1031): 0: 985: 100.00		PLXA1_MOUSE (19-1893): 0: 2404: 63.46
+	Mm
		139669 SEM3A_MOUSE (4-666): 0: 676: 28.38		PLXA4_MOUSE (1-1893): 0: 2673: 100.00
+	Mm
		222745 SEM6B_MOUSE (2-883): 0: 615: 41.56		PLXA4_MOUSE (1-1893): 0: 2673: 100.00
+	Mm
		936310 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA2_MOUSE (9-1893): 0: 2458: 66.86
+	Mm
		936300 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA1_MOUSE (19-1893): 0: 2404: 63.46
+	Mm
		936315 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA3_MOUSE (9-1893): 0: 2343: 59.66
+	Mm
		936311 SEM3D_MOUSE (4-654): 0: 664: 27.66		PLXA2_MOUSE (9-1893): 0: 2458: 66.86
+	Mm
		222744 SEM6B_MOUSE (2-883): 0: 615: 41.56		PLXA2_MOUSE (9-1893): 0: 2458: 66.86
+	Mm
		1112528 SEM3D_MOUSE (4-654): 0: 664: 27.66		PLXD1_MOUSE (40-1892): 0: 1894: 31.40
+	Hs
		165243 SEM4C_HUMAN (1-672): 0: 596: 26.44		PLXB2_HUMAN (35-1891): 0: 1958: 31.93
+	Mm
		936364 SEM3E_MOUSE (14-655): 0: 637: 25.53		PLXD1_MOUSE (40-1892): 0: 1894: 31.40
+	Mm
		71305 SEM4C_MOUSE (1-672): 0: 593: 27.12		PLXB2_MOUSE (35-1891): 0: 1926: 31.79
+	Hs
		165342 SEM3E_HUMAN (14-655): 0: 632: 25.68		PLXD1_HUMAN (40-1892): 0: 1862: 31.44
+	Mm
		1176229 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXC1_MOUSE (62-956): 1.02e-108: 385: 17.14
+	Mm
		139662 SEM3A_MOUSE (4-666): 0: 676: 28.38		SEM3A_MOUSE (10-599): 3.68e-134: 440: 15.23
+	Hs
		1055532 SEM3C_HUMAN (2-638): 0: 635: 27.25		SEM3A_HUMAN (4-599): 3.79e-130: 429: 15.05
+	Hs
		303598 SEM3C_HUMAN (2-638): 0: 635: 27.25		SEM3D_HUMAN (3-560): 1.12e-121: 405: 16.61
+	Hs
		1318972 SEM4C_HUMAN (1-672): 0: 596: 26.44		SEM4A_HUMAN (25-592): 2.76e-121: 403: 17.48