Protein: RPB4
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (B32) (DNA-directed RNA polymerase II 32 kDa polypeptide)

Gene: RPB4
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P20433

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000932 - P-body
GO:0001172 - RNA-templated transcription
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

632075

RPB7
DNA-directed RNA polymerase II subunit RPB7

31

4

Small-scale

0.992

High

401879

RPB1
DNA-directed RNA polymerase II subunit RPB1

18

8

Small-scale

0.983

High

470456

RPB2
DNA-directed RNA polymerase II subunit RPB2

8

3

Small-scale

0.961

High

594175

RPB3
DNA-directed RNA polymerase II subunit RPB3

32

4

Small-scale

0.768

High

632060

SPT6
Transcription elongation factor SPT6

2

1

Small-scale

0.754

High

632106

MCE1
mRNA-capping enzyme subunit alpha

2

1

Small-scale

0.754

High

632055

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

11

1

Small-scale

0.752

High

632063

RPB9
DNA-directed RNA polymerase II subunit RPB9

9

4

Small-scale

0.749

High

632056

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

7

1

Small-scale

0.741

High

632057

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

7

1

Small-scale

0.739

High

632085

RPB11
DNA-directed RNA polymerase II subunit RPB11

7

2

Small-scale

0.739

High

632069

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.716

High

632062

SPT5
Transcription elongation factor SPT5

5

1

Small-scale

0.714

High

632058

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

1

Small-scale

0.706

High

632096

T2FB
Transcription initiation factor IIF subunit beta

6

0

Small-scale

0.695

High

441033

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.691

High

441324

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.691

High

632117

IWR1
RNA polymerase II nuclear localization protein IWR1

5

0

Small-scale

0.682

High

632093

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

1

Small-scale

0.676

High

632077

TAF14
Transcription initiation factor TFIID subunit 14

5

0

Small-scale

0.676

High

632072

SPT4
Transcription elongation factor SPT4

4

0

Small-scale

0.653

High

632091

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

3

1

Small-scale

0.640

High

632098

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

3

1

Small-scale

0.640

High

619396

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

Small-scale

0.633

High

632102

NRD1
Protein NRD1

2

1

Small-scale

0.628

High

534210

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

8

Small-scale

0.618

High

632067

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

0

Small-scale

0.618

High

632095

T2FA
Transcription initiation factor IIF subunit alpha

3

0

Small-scale

0.613

High

632116

ASR1
Alcohol-sensitive RING finger protein 1

3

0

Small-scale

0.613

High

632064

TF2B
Transcription initiation factor IIB

2

1

Small-scale

0.584

High

632068

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.559

High

632105

SEN1
Helicase SEN1

2

0

Small-scale

0.559

High

632103

SUB1
RNA polymerase II transcriptional coactivator SUB1

1

0

Small-scale

0.537

High

632090

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

High-throughput

0.536

High

632061

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

Small-scale

0.529

High

547847

NHP6B
Non-histone chromosomal protein 6B

1

2

Small-scale

0.527

High

632065

XPO1
Exportin-1

1

0

High-throughput

0.513

High

632082

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

Small-scale

0.513

High

632097

ELP2
Elongator complex protein 2

1

0

Small-scale

0.513

High

632092

RAD26
DNA repair and recombination protein RAD26

1

1

Small-scale

0.501

High

438251

NOT3
General negative regulator of transcription subunit 3

1

1

Small-scale

0.481

High

547756

NHP6A
Non-histone chromosomal protein 6A

1

2

Small-scale

0.481

High

632120

NOT5
General negative regulator of transcription subunit 5

1

1

Small-scale

0.481

High

632087

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.480

High

632101

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

Small-scale

0.480

High

381392

H2B2
Histone H2B.2

1

3

High-throughput

0.479

High

454555

TFS2
Transcription elongation factor S-II

1

1

Small-scale

0.479

High

632079

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.479

High

632108

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

Small-scale

0.479

High

632109

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

632111

RT103
Regulator of Ty1 transposition protein 103

1

4

Small-scale

0.479

High

632066

SFP1
Transcription factor SFP1

1

0

Small-scale

0.460

High

632080

LSM2
LSM complex subunit LSM2

1

0

Small-scale

0.460

High

419589

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

438380

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.458

High

632054

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

632070

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

632071

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

632073

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

Small-scale

0.458

High

632078

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

632083

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

Small-scale

0.458

High

632086

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

0

Small-scale

0.458

High

632094

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

632100

RRP46
Exosome complex component RRP46

1

0

Small-scale

0.458

High

632104

H3
Histone H3

1

0

Small-scale

0.458

High

632107

NOP3
Serine/arginine

1

0

Small-scale

0.458

High

632113

PDP3
NuA3 HAT complex component PDP3

1

0

Small-scale

0.458

High

632114

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

632115

CDC73
Cell division control protein 73

1

0

High-throughput

0.458

High

632118

PUF3
mRNA-binding protein PUF3

1

0

Small-scale

0.458

High

632119

NCBP2
Nuclear cap-binding protein subunit 2

1

0

Small-scale

0.458

High

632081

TRM7
tRNA

1

0

High-throughput

0.438

High

632099

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

632110

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

523026

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

632059

AIM17
Probable oxidoreductase AIM17

2

0

High-throughput

0.307

High

148857

CET1
mRNA-capping enzyme subunit beta

2

0

Small-scale

0.305

High

632112

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.303

High

513948

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

622317

ACON
Aconitate hydratase, mitochondrial

1

0

Small-scale

0.249

Low

632074

PAD1
Flavin prenyltransferase PAD1, mitochondrial

1

0

Small-scale

0.249

Low

632076

SC61G
Protein transport protein SSS1

1

0

Small-scale

0.249

Low

632084

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

632088

LAA1
AP-1 accessory protein LAA1

1

0

Small-scale

0.249

Low

632089

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025