HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.951

Property	Details
Experiments	10359822, 14742442, 15070676, 19282476, 18927629, 20581311, 20304921
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0050728 - negative regulation of inflammatory response GO:0097398 - cellular response to interleukin-17
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 770
+	Hs
		147400 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		146671 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Mm
		403422 SRC_MOUSE (34-179): 1.48e-35: 133: 19.61		STAT3_MOUSE (1-770): 0: 1050: 100.00
+	Hs
		412065 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		454804 FGR_HUMAN (34-178): 9.43e-36: 133: 19.08		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		522829 SRC_HUMAN (34-179): 1.12e-35: 133: 19.61		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		776638 GRB2_HUMAN (34-174): 7.66e-35: 124: 14.79		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		655247 P85A_HUMAN (14-153): 2.72e-22: 96.4: 16.43		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		776765 P55G_HUMAN (14-153): 2.59e-22: 96: 19.01		STAT3_HUMAN (1-770): 0: 1047: 99.87
+	Hs
		256851 SOCS5_HUMAN (23-221): 1.3e-39: 144: 21.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		522836 SRC_HUMAN (34-179): 1.12e-35: 133: 19.61		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		146609 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		786656 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		STA5A_MOUSE (1-734): 0: 758: 30.46
+	Hs
		849911 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786637 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		146672 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		193381 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		STAT6_MOUSE (1-761): 0: 668: 25.69
+	Hs
		849903 P55G_HUMAN (14-153): 2.59e-22: 96: 19.01		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Dm
		1096415 Q8INY1_DROME (21-221): 5.4e-46: 163: 22.66		STAT_DROME (1-755): 0: 648: 22.58
+	Dm
		1096410 Q7JVF1_DROME (26-219): 1.56e-40: 143: 19.29		STAT_DROME (1-755): 0: 648: 22.58