Protein: LAT
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)

Gene: LAT
Organism: Homo sapiens
Interactions: 114
UniProt ID: O43561

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0002260 - lymphocyte homeostasis
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220350

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

8

2

Small-scale

0.756

High

220367

GRB2
Growth factor receptor-bound protein 2

9

9

Small-scale

0.752

High

220354

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

1

Small-scale

0.681

High

220324

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

3

1

High-throughput

0.675

High

220332

EGFR
Epidermal growth factor receptor

3

2

High-throughput

0.672

High

220358

ZAP70
Tyrosine-protein kinase ZAP-70

3

6

Small-scale

0.651

High

220337

LCK
Tyrosine-protein kinase Lck

2

4

Small-scale

0.649

High

220347

VAV
Proto-oncogene vav

2

6

Small-scale

0.629

High

220348

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

2

Small-scale

0.629

High

220328

GRAP2
GRB2-related adapter protein 2

2

10

Small-scale

0.624

High

220349

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

Small-scale

0.610

High

138546

CLD5
Claudin-5

2

2

High-throughput

0.606

High

166082

FFAR3
Free fatty acid receptor 3

2

3

High-throughput

0.606

High

194655

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

220331

CLD7
Claudin-7

2

2

High-throughput

0.606

High

220360

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

1

High-throughput

0.606

High

220361

CXA8
Gap junction alpha-8 protein

2

2

High-throughput

0.606

High

220366

CLD2
Claudin-2

2

2

High-throughput

0.606

High

220380

MF14B
Hippocampus abundant transcript-like protein 1

2

2

High-throughput

0.606

High

220385

LHPL1
LHFPL tetraspan subfamily member 1 protein

2

1

High-throughput

0.606

High

220393

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.606

High

220394

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.606

High

220395

GP151
G-protein coupled receptor 151

2

1

High-throughput

0.606

High

220402

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.606

High

220406

GP101
Probable G-protein coupled receptor 101

2

1

High-throughput

0.606

High

220424

ZDHC7
Palmitoyltransferase ZDHHC7

2

2

High-throughput

0.606

High

220369

ITK
Tyrosine-protein kinase ITK/TSK

2

4

Small-scale

0.595

High

220373

GRAP
GRB2-related adapter protein

2

9

Small-scale

0.595

High

220353

CBL
E3 ubiquitin-protein ligase CBL

2

2

Small-scale

0.584

High

220375

SHB
SH2 domain-containing adapter protein B

2

8

Small-scale

0.584

High

220336

SLPI
Antileukoproteinase

2

0

High-throughput

0.580

High

220339

ASGR2
Asialoglycoprotein receptor 2

2

0

High-throughput

0.580

High

220344

CD3G
T-cell surface glycoprotein CD3 gamma chain

2

0

High-throughput

0.580

High

220351

CD53
Leukocyte surface antigen CD53

2

0

High-throughput

0.580

High

220356

OPRM
Mu-type opioid receptor

2

0

High-throughput

0.580

High

220363

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

2

0

High-throughput

0.580

High

220376

UT2
Urea transporter 2

2

0

High-throughput

0.580

High

220378

CX066
Uncharacterized protein CXorf66

2

0

High-throughput

0.580

High

220383

MFSD5
Molybdate-anion transporter

2

0

High-throughput

0.580

High

220384

OSTB
Organic solute transporter subunit beta

2

0

High-throughput

0.580

High

220391

SYT2
Synaptotagmin-2

2

0

High-throughput

0.580

High

220392

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.580

High

220396

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

220399

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.580

High

220400

APH1A
Gamma-secretase subunit APH-1A

2

0

High-throughput

0.580

High

220401

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.580

High

220404

TMM80
Transmembrane protein 80

2

0

High-throughput

0.580

High

220407

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

220412

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.580

High

220413

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.580

High

220415

S19A3
Thiamine transporter 2

2

0

High-throughput

0.580

High

220416

MS4A7
Membrane-spanning 4-domains subfamily A member 7

2

0

High-throughput

0.580

High

220422

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.580

High

220425

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.580

High

220371

LCP2
Lymphocyte cytosolic protein 2

2

1

Small-scale

0.571

High

220388

THMS1
Protein THEMIS

2

1

Small-scale

0.570

High

220325

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

220355

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

Small-scale

0.561

High

220427

TRAF6
TNF receptor-associated factor 6

2

0

Small-scale

0.559

High

220327

CXB3
Gap junction beta-3 protein

2

2

High-throughput

0.553

High

220342

CXB1
Gap junction beta-1 protein

2

2

High-throughput

0.553

High

220338

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.550

High

220370

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

1

Small-scale

0.550

High

220368

3BP2
SH3 domain-binding protein 2

2

1

Small-scale

0.543

High

220381

ZDH20
Palmitoyltransferase ZDHHC20

1

1

High-throughput

0.536

High

220421

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.536

High

193377

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

220335

ALBU
Albumin

1

0

High-throughput

0.513

High

220418

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

220359

KSYK
Tyrosine-protein kinase SYK

1

7

Small-scale

0.501

High

220341

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

220345

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

1

Small-scale

0.479

High

220346

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

1

Small-scale

0.479

High

220372

SLAP1
Src-like-adapter

1

5

Small-scale

0.479

High

220398

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

Small-scale

0.479

High

220426

GAB2
GRB2-associated-binding protein 2

1

1

Small-scale

0.479

High

116990

J3KQ12
Seipin

1

1

High-throughput

0.470

High

220382

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

220357

MOT8
Monocarboxylate transporter 8

1

0

High-throughput

0.460

High

220409

SERC2
Serine incorporator 2

1

0

High-throughput

0.460

High

220323

SPY1
Protein sprouty homolog 1

1

0

Small-scale

0.458

High

220326

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.458

High

220329

FLOT1
Flotillin-1

1

0

Small-scale

0.458

High

220340

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.458

High

220343

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

220352

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.458

High

220362

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

0

Small-scale

0.458

High

220374

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

0

Small-scale

0.458

High

220410

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

220364

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

220403

BSCL2
Seipin

1

1

High-throughput

0.439

High

220330

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

1

High-throughput

0.437

High

71826

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

220365

VMAT1
Chromaffin granule amine transporter

2

0

High-throughput

0.316

High

220377

PROL4
Proline-rich protein 4

2

0

High-throughput

0.316

High

220387

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

220389

KCD17
BTB/POZ domain-containing protein KCTD17

2

0

High-throughput

0.316

High

220397

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.316

High

220405

JSPR1
Junctional sarcoplasmic reticulum protein 1

2

0

High-throughput

0.316

High

220411

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

220414

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

0

High-throughput

0.316

High

220417

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

220419

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

220420

CDIP1
Cell death-inducing p53-target protein 1

2

0

High-throughput

0.316

High

220423

SAR1A
Small COPII coat GTPase SAR1A

2

0

High-throughput

0.316

High

220428

RT18B
Small ribosomal subunit protein mS40

2

0

High-throughput

0.316

High

220429

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

220390

KASH5
Protein KASH5

1

0

High-throughput

0.292

High

220430

ZHX2
Zinc fingers and homeoboxes protein 2

1

0

High-throughput

0.282

High

220408

LMF1
Lipase maturation factor 1

1

0

High-throughput

0.279

Low

220333

CO1A1
Collagen alpha-1(I) chain

1

0

High-throughput

0.269

Low

220334

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

220379

F209A
Protein FAM209A

1

0

High-throughput

0.251

Low

220386

CLYBL
Citramalyl-CoA lyase, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025