HitPredict

Interactor 1: ASAP2 (O43150)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)
Gene: ASAP2

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, PH~SH3_1, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1006 Hs			1 304
+	Hs
		195785 ASAP2_HUMAN (1-1006): 0: 661: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		195791 ASAP2_HUMAN (1-1006): 0: 661: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		195770 ASAP2_HUMAN (1-1006): 0: 661: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		195783 ASAP2_HUMAN (1-1006): 0: 661: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		195795 ASAP2_HUMAN (1-1006): 0: 661: 100.00		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		195796 ASAP2_HUMAN (1-1006): 0: 661: 100.00		Q5JPT6_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		195804 ASAP2_HUMAN (1-1006): 0: 661: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		802672 ASAP3_HUMAN (1-865): 5.63e-153: 478: 43.96		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802877 ASAP3_HUMAN (1-865): 5.63e-153: 478: 43.96		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		63069 RHG42_HUMAN (23-1004): 3.41e-85: 295: 13.07		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		924582 ACAP1_HUMAN (23-678): 3.93e-128: 407: 19.97		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		63070 RHG42_HUMAN (23-1004): 3.41e-85: 295: 13.07		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		557696 ACAP1_HUMAN (23-678): 3.93e-128: 407: 19.97		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Rn
		499164 AGAP2_RAT (136-646): 2.72e-79: 283: 18.39		PLCG1_RAT (8-302): 1.46e-26: 111: 15.72
+	Hs
		802704 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		924798 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209145 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557775 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		1285175 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		209187 ASAP1_HUMAN (749-1006): 4.17e-17: 88.8: 26.74		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00