Protein: ACT1
Actin-5C (EC 3.6.4.-)

Gene: ACT1, Act5C
Organism: Drosophila melanogaster
Interactions: 137
UniProt ID: P10987

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006338 - chromatin remodeling
GO:0007291 - sperm individualization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534416

BRM
ATP-dependent helicase brm

5

17

Small-scale

0.912

High

534491

Q9VPX6
Adenylyl cyclase-associated protein

2

20

Small-scale

0.757

High

534438

MICAL
[F-actin]-monooxygenase Mical

2

19

Small-scale

0.696

High

534417

FAS2
Fasciclin-2

1

1

High-throughput

0.691

High

534463

SPIR
Protein spire

3

5

Small-scale

0.678

High

304914

CRY1
Cryptochrome-1

2

1

Small-scale

0.620

High

122286

M9PI41
non-specific serine/threonine protein kinase

1

7

Small-scale

0.618

High

534413

SPTCA
Spectrin alpha chain

1

20

Small-scale

0.618

High

534457

Q94533
Ribosomal protein S6 kinase

1

11

High-throughput

0.618

High

534492

Q9VPX7
Capulet, isoform A

1

20

High-throughput

0.590

High

387022

ACT4
Actin, larval muscle

1

18

High-throughput

0.575

High

534341

ACT5
Actin-87E

1

18

High-throughput

0.575

High

534418

ACT3
Actin-57B

1

18

High-throughput

0.575

High

534446

Q8IQZ7
FI19014p1

1

20

High-throughput

0.575

High

534512

Q9VZN2
GH21062p

1

13

High-throughput

0.555

High

95332

E1JIQ4
Mitochondrial calcium uptake 3, isoform C

1

1

High-throughput

0.553

High

534520

Q9W4A9
Rho GTPase activating protein at 5A, isoform A

1

17

High-throughput

0.553

High

534494

Q9VQ94
LP05220p

1

0

High-throughput

0.549

High

534448

PHO
Polycomb protein PHO

1

7

Small-scale

0.536

High

534511

Q9VZM9
RE59328p

1

14

High-throughput

0.528

High

69056

A8JRH3
FI20012p1

1

11

High-throughput

0.514

High

534516

CAPZA
F-actin-capping protein subunit alpha

1

9

High-throughput

0.514

High

534496

Q9VSB2
Uncharacterized protein, isoform A

1

16

High-throughput

0.508

High

534519

Q9W3V9
Nuclear transcription factor Y subunit gamma

1

3

High-throughput

0.508

High

534472

Q9VF03
Brahma associated protein 155 kDa

1

9

Small-scale

0.501

High

305328

O77291
Kakapo

1

20

High-throughput

0.492

High

534423

QUAI
Villin-like protein quail

1

20

High-throughput

0.492

High

534434

Q7KN55
Adenylyl cyclase-associated protein

1

20

High-throughput

0.492

High

534474

TWF
Twinfilin

1

20

High-throughput

0.492

High

194922

MBL
Protein muscleblind

1

0

High-throughput

0.486

High

534431

ADRM1
Proteasomal ubiquitin receptor ADRM1 homolog

1

0

High-throughput

0.486

High

534464

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.486

High

534465

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.486

High

534515

TAMO
Protein tamozhennic

1

0

High-throughput

0.486

High

534439

Q86BH2
Grunge, isoform C

1

5

Small-scale

0.481

High

120267

M9PD17
Gigas, isoform B

1

3

High-throughput

0.479

High

120908

M9PEG0
Girdin, isoform D

1

20

Small-scale

0.479

High

534414

DDX6
ATP-dependent RNA helicase me31b

1

5

High-throughput

0.479

High

534415

OSKA
Maternal effect protein oskar

1

4

Small-scale

0.479

High

534422

GAGA
Transcription activator GAGA

1

9

Small-scale

0.479

High

534432

Q7K490
SD03973p

1

8

High-throughput

0.479

High

534441

LASP1
LIM and SH3 domain protein Lasp

1

20

Small-scale

0.479

High

534444

OSA
Trithorax group protein osa

1

10

Small-scale

0.479

High

534447

CASP8
Caspase-8

1

5

Small-scale

0.479

High

534450

Q8T0T2
GH09296p

1

5

Small-scale

0.479

High

534456

DNAT
Arylalkylamine N-acetyltransferase 1

1

1

High-throughput

0.479

High

534460

FOXO
Forkhead box protein O

1

1

High-throughput

0.479

High

534466

ANLN
Anillin

1

10

Small-scale

0.479

High

534482

Q9VKQ5
GEO07393p1

1

2

High-throughput

0.479

High

534501

PYRG
CTP synthase

1

2

High-throughput

0.479

High

534502

OSGEP
Probable tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.479

High

534425

NOC
Zinc finger protein Noc

1

8

High-throughput

0.464

High

534428

Q4V480
Cuticular protein 92A

1

9

High-throughput

0.464

High

534443

Q8IMX4
FI04408p

1

4

High-throughput

0.464

High

534452

PUF68
Poly(U)-binding-splicing factor hfp

1

5

High-throughput

0.464

High

534455

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.464

High

534461

LAR4
La-related protein Larp4B

1

11

High-throughput

0.464

High

534483

Q9VLS8
LD29807p

1

2

High-throughput

0.464

High

534510

Q9VZF9
Cuticular protein 64Ad

1

9

High-throughput

0.464

High

534517

OR9A
Odorant receptor 9a

1

2

High-throughput

0.464

High

197301

O18335
Rab11

1

0

Small-scale

0.458

High

534421

P91634
phosphatidylinositol 3-kinase

1

0

High-throughput

0.458

High

534435

Q7KN61
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.458

High

534518

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

52080

A1Z6M0
Brahma associated protein 170kD

1

8

Small-scale

0.445

High

534485

Q9VM12
MIP26555p1

1

2

High-throughput

0.445

High

534503

SMN
Survival motor neuron protein

1

1

High-throughput

0.445

High

95360

E1JJ00
Uncharacterized protein, isoform D

1

3

High-throughput

0.439

High

96054

E8NH67
Asperous, isoform B

1

1

High-throughput

0.439

High

98440

F0JAG2
MIP27703p

1

3

High-throughput

0.439

High

120022

M9PC39
Trissin receptor, isoform D

1

8

High-throughput

0.439

High

534454

Q8T9K8
GM02327p

1

8

High-throughput

0.439

High

534475

Q9VG05
Uncharacterized protein, isoform H

1

12

High-throughput

0.439

High

534497

Q9VT68
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.439

High

534505

Q9VXI3
Endoplasmic reticulum protein 44, isoform C

1

3

High-throughput

0.439

High

534525

X2JCD3
Uncharacterized protein, isoform D

1

4

High-throughput

0.439

High

518447

AST5
Achaete-scute complex protein T5

1

4

Small-scale

0.437

High

518478

AST4
Achaete-scute complex protein T4

1

5

Small-scale

0.437

High

534412

DA
Protein daughterless

1

1

Small-scale

0.437

High

534449

Q8SXB3
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

1

High-throughput

0.437

High

534451

Q8T3J1
SD02419p

1

1

High-throughput

0.437

High

534471

Q9VEV3
Tetratricopeptide repeat protein 1

1

12

High-throughput

0.437

High

534477

UFL1
E3 UFM1-protein ligase 1 homolog

1

4

High-throughput

0.437

High

534487

ORCO
Odorant receptor coreceptor

1

2

Small-scale

0.437

High

534488

RHEB
GTP-binding protein Rheb homolog

1

4

High-throughput

0.437

High

534499

Q9VTY1
LD40136p

1

2

High-throughput

0.437

High

534507

PGPLE
Peptidoglycan-recognition protein LE

1

5

High-throughput

0.437

High

534513

Q9VZS1
protein-serine/threonine phosphatase

1

2

High-throughput

0.437

High

534514

Q9W0X1
GH15894p

1

2

High-throughput

0.437

High

534522

Q9W4L9
IP04124p

1

1

High-throughput

0.437

High

57702

A1ZB72
Glutathione S transferase E7

1

0

High-throughput

0.426

High

534459

Q95TP0
LD34582p

1

0

High-throughput

0.426

High

234961

O46085
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.417

High

534420

HEM
Membrane-associated protein Hem

1

5

Small-scale

0.417

High

534440

Q86BI3
Zinc-finger protein at 72D, isoform B

1

3

High-throughput

0.417

High

534445

Q8INH9
Uncharacterized protein, isoform J

1

12

High-throughput

0.417

High

534453

Q8T9G7
SD01558p

1

2

High-throughput

0.417

High

534458

Q95TL8
Endoplasmic reticulum protein 44, isoform A

1

3

High-throughput

0.417

High

534486

TRISR
Trissin receptor

1

8

High-throughput

0.417

High

534498

Q9VT69
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.417

High

534500

Q9VU13
LD45603p

1

5

High-throughput

0.417

High

534523

Q9W533
Uncharacterized protein, isoform D

1

8

High-throughput

0.417

High

534524

Q9W5X1
Asperous, isoform A

1

1

High-throughput

0.417

High

357243

O97428
Ciboulot, isoform A

1

0

High-throughput

0.411

High

534419

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

1

High-throughput

0.407

High

534430

Q7K0A2
Cuticular protein 47Eb

1

7

High-throughput

0.407

High

534436

RS15B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.407

High

534437

Q7KSK8
BcDNA.GH09045

1

3

High-throughput

0.407

High

534442

Q8IGZ8
LP05231p

1

8

High-throughput

0.407

High

534467

Q9V9P0
Uncharacterized protein, isoform B

1

2

High-throughput

0.407

High

534469

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.407

High

534480

EFHD2
EF-hand domain-containing protein D2 homolog

1

3

High-throughput

0.407

High

534484

Q9VLV6
LD40565p

1

9

High-throughput

0.407

High

534506

Q9VXN3
LD07988p

1

12

High-throughput

0.407

High

534424

Q24339
Aberrant large forked product

1

7

High-throughput

0.381

High

534426

SING
Protein singed

1

1

High-throughput

0.381

High

534470

Q9VDK2
GH15831p

1

0

High-throughput

0.265

Low

534476

Q9VGG3
LD35413p

1

0

High-throughput

0.265

Low

534481

Q9VK43
LD10135p

1

0

High-throughput

0.265

Low

534493

INT14
Integrator complex subunit 14

1

0

High-throughput

0.265

Low

534508

Q9VY61
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

534509

Q9VZB1
Pupal cuticle protein Edg-91

1

0

High-throughput

0.265

Low

534521

Q9W4K0
CHOp24, isoform A

1

0

High-throughput

0.265

Low

68877

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

0

High-throughput

0.249

Low

534427

SRF
Serum response factor homolog

1

0

High-throughput

0.249

Low

534433

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.249

Low

534462

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.249

Low

534468

Q9VA35
CIN85 and CD2AP related, isoform A

1

0

Small-scale

0.249

Low

534473

Q9VF68
CG6130 protein

1

0

High-throughput

0.249

Low

534495

Q9VRF5
Central complex broad

1

0

Small-scale

0.249

Low

50203

A1A6X5
GEO11044p1

1

0

High-throughput

0.232

Low

534429

Q6NMT8
AT01712p

1

0

High-throughput

0.232

Low

534478

Q9VIC3
carboxylesterase

1

0

High-throughput

0.232

Low

534479

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.232

Low

534489

Q9VNN9
Osiris 17, isoform A

1

0

High-throughput

0.232

Low

534490

Q9VP44
Earthbound 2, isoform A

1

0

High-throughput

0.232

Low

534504

Q9VVH7
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025