HitPredict

Interactor 1: SERA (O43175)
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)
Gene: PHGDH

Interactor 2: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34732716
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007420 - brain development GO:0010468 - regulation of gene expression
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 533 Hs			1 317
+	Hs
		817843 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		818014 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Mm
		1142013 Q91YZ2_MOUSE (21-383): 6.14e-122: 366: 28.57		Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24
+	Hs
		881308 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75
+	Hs
		881337 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		SOX13_HUMAN (29-192): 1.22e-34: 134: 28.05
+	Hs
		1032636 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75
+	Hs
		1032565 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26
+	Hs
		727840 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61
+	Hs
		996651 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		727862 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61
+	Dm
		220645 CTBP_DROME (4-319): 1.05e-102: 318: 28.10		Q59DN5_DROME (12-127): 3.31e-39: 147: 42.24