HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 889
+	Hs
		925589 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		436490 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		951303 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		894394 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		545597 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		545575 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		900901 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		925615 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		436507 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		951338 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		OSBL3_HUMAN (250-757): 1.65e-143: 449: 18.81
+	Hs
		900859 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		925582 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		951289 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		894383 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		545593 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		OSB10_HUMAN (283-749): 1.96e-139: 435: 29.46
+	Hs
		900858 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		925581 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		951288 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		545592 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Sc
		419682 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		KES1_YEAST (399-733): 5.95e-92: 299: 26.83