HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 217
+	Hs
		924703 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		199501 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		199495 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		199497 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		199500 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		639451 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Mm
		403448 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		411721 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411790 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		557691 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337474 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		222878 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Hs
		557740 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		412193 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		297808 K0754_HUMAN (34-464): 4e-33: 137: 13.71		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433761 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433891 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		412152 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433331 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91