HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.80	0.702

Property	Details
Experiments	16189514, 31515488
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CAS_C~RasGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 860
+	Mm
		192350 CASL_MOUSE (5-349): 2e-33: 137: 23.68		SH2D3_MOUSE (1-860): 0: 851: 86.40
+	Hs
		275570 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		199497 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		199500 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		199508 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Mm
		403448 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		SRC_MOUSE (20-425): 9.19e-63: 222: 13.68
+	Hs
		199507 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Mm
		639451 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		LYN_MOUSE (110-394): 1.53e-53: 196: 11.59
+	Hs
		199502 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Hs
		412193 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		199510 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		199489 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		297808 K0754_HUMAN (34-464): 4e-33: 137: 13.71		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		433761 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Mm
		192348 CASL_MOUSE (5-349): 2e-33: 137: 23.68		CRK_MOUSE (209-512): 1.83e-53: 190: 16.06
+	Hs
		411721 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		199505 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58
+	Hs
		802600 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		802843 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		CRKL_HUMAN (220-480): 2.1e-51: 184: 18.12