HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	12829691, 19531213
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 665
+	Hs
		166055 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		203208 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		203218 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		203228 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		203191 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		166060 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		203192 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Rn
		192744 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SRBS2_RAT (3-155): 3.11e-11: 68.9: 30.25
+	Hs
		166030 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		166042 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (254-450): 4.79e-13: 74.7: 12.56
+	Ce
		105281 SYNJ_CAEEL (5-1160): 0: 938: 39.64		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48
+	Mm
		1246940 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		1271562 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		1141165 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		557759 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924742 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91