Protein: TOP2
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)

Gene: TOP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: P06786

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000722 - telomere maintenance via recombination
GO:0000795 - synaptonemal complex
GO:0000819 - sister chromatid segregation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448908

TOP2
DNA topoisomerase 2

9

16

Small-scale

0.970

High

419548

H2A2
Histone H2A.2

3

7

High-throughput

0.650

High

448938

SPT16
FACT complex subunit SPT16

3

1

High-throughput

0.650

High

449006

POB3
FACT complex subunit POB3

3

4

High-throughput

0.650

High

449029

SMT3
Ubiquitin-like protein SMT3

3

4

High-throughput

0.645

High

448973

ATAD2
ATPase histone chaperone YTA7

3

2

Small-scale

0.640

High

449036

CMR1
DNA damage-binding protein CMR1

3

10

High-throughput

0.640

High

448957

OLA1
Obg-like ATPase 1

2

2

High-throughput

0.621

High

449027

YRA1
RNA annealing protein YRA1

2

1

High-throughput

0.621

High

448945

DRS1
ATP-dependent RNA helicase DRS1

1

2

High-throughput

0.618

High

448920

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.611

High

381359

H2B2
Histone H2B.2

2

15

High-throughput

0.601

High

448913

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.601

High

449011

PDP3
NuA3 HAT complex component PDP3

2

2

High-throughput

0.601

High

448996

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.595

High

449003

SIZ1
E3 SUMO-protein ligase SIZ1

2

4

Small-scale

0.595

High

448959

RFC5
Replication factor C subunit 5

2

1

High-throughput

0.588

High

381790

H4
Histone H4

2

4

High-throughput

0.584

High

448978

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

448995

H3
Histone H3

2

10

High-throughput

0.584

High

449037

H2AZ
Histone H2A.Z

2

8

High-throughput

0.584

High

448993

APJ1
J domain-containing protein APJ1

2

5

High-throughput

0.571

High

448925

KPC1
Protein kinase C-like 1

1

7

Small-scale

0.568

High

448911

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

449039

YB111
Uncharacterized helicase-like protein YBL111C

1

0

High-throughput

0.546

High

448939

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.536

High

448972

TBP6
Probable 26S proteasome subunit YTA6

1

2

High-throughput

0.536

High

448989

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

449035

NOP56
Nucleolar protein 56

1

2

High-throughput

0.536

High

449022

ULS1
ATP-dependent helicase ULS1

1

4

Small-scale

0.527

High

448921

PYRC
Dihydroorotase

1

0

High-throughput

0.518

High

448916

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.515

High

448965

DUN1
DNA damage response protein kinase DUN1

1

0

High-throughput

0.513

High

449032

RNH2C
Ribonuclease H2 subunit C

1

0

High-throughput

0.513

High

425093

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.500

High

448910

SSBP1
Single-stranded nucleic acid-binding protein

1

3

High-throughput

0.500

High

448951

BMH2
Protein BMH2

1

2

High-throughput

0.500

High

448922

REB1
DNA-binding protein REB1

1

0

High-throughput

0.493

High

448964

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.493

High

448969

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.493

High

448990

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.493

High

449019

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.493

High

448982

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.489

High

448929

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

Small-scale

0.486

High

403302

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

448914

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

448927

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.479

High

380919

H2B1
Histone H2B.1

1

15

High-throughput

0.479

High

434689

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

448917

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

448923

RFA1
Replication factor A protein 1

1

2

Small-scale

0.479

High

448928

RSC6
Chromatin structure-remodeling complex protein RSC6

1

2

High-throughput

0.479

High

448930

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

448931

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

448932

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

448933

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.479

High

448935

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

448941

STH1
Nuclear protein STH1/NPS1

1

7

High-throughput

0.479

High

448942

CHD1
Chromo domain-containing protein 1

1

8

High-throughput

0.479

High

448944

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

448950

SAS3
Histone acetyltransferase SAS3

1

1

High-throughput

0.479

High

448952

BDF1
Bromodomain-containing factor 1

1

15

High-throughput

0.479

High

448953

CENPA
Histone H3-like centromeric protein CSE4

1

10

High-throughput

0.479

High

448955

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

9

High-throughput

0.479

High

448961

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

448962

RSC30
Chromatin structure-remodeling complex protein RSC30

1

1

High-throughput

0.479

High

448974

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.479

High

448977

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

448980

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.479

High

448986

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

448991

NOP13
Nucleolar protein 13

1

4

High-throughput

0.479

High

448994

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

449001

HOS3
Histone deacetylase HOS3

1

5

High-throughput

0.479

High

449007

ARP9
Actin-like protein ARP9

1

1

High-throughput

0.479

High

449009

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

449010

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

1

High-throughput

0.479

High

449013

IWS1
Transcription factor SPN1

1

1

High-throughput

0.479

High

449015

RSC3
Chromatin structure-remodeling complex protein RSC3

1

1

High-throughput

0.479

High

449016

BDF2
Bromodomain-containing factor 2

1

14

High-throughput

0.479

High

449023

YTM1
Ribosome biogenesis protein YTM1

1

10

High-throughput

0.479

High

449025

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

449028

SIZ2
E3 SUMO-protein ligase SIZ2

1

4

High-throughput

0.479

High

449030

NTO1
NuA3 HAT complex component NTO1

1

1

High-throughput

0.479

High

449033

ARP7
Actin-related protein 7

1

2

High-throughput

0.479

High

449034

EAF3
Chromatin modification-related protein EAF3

1

1

High-throughput

0.479

High

449038

SMC6
Structural maintenance of chromosomes protein 6

1

4

Small-scale

0.479

High

448915

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

448924

APN1
Apurinic-apyrimidinic endonuclease 1

1

0

High-throughput

0.458

High

448943

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

448946

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

448947

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

448954

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

448971

RT106
Histone chaperone RTT106

1

0

High-throughput

0.458

High

448976

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.458

High

448987

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

448988

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

448992

CBK1
Serine/threonine-protein kinase CBK1

1

0

Small-scale

0.458

High

448999

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

449000

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

449002

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.458

High

449005

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.458

High

449014

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

449018

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.458

High

449021

SGO1
Shugoshin

1

0

High-throughput

0.458

High

449026

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

449041

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.458

High

416983

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.445

High

448909

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

448912

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

448918

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

448926

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

448934

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

448940

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

448948

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

448963

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

448968

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

448970

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

448983

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.445

High

449008

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

10

High-throughput

0.445

High

448984

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

448997

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.437

High

448998

MLP1
Protein MLP1

1

7

High-throughput

0.437

High

449012

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

19

High-throughput

0.437

High

449017

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

449020

BRX1
Ribosome biogenesis protein BRX1

1

1

High-throughput

0.437

High

448966

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

449040

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

448960

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.407

High

448967

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.407

High

448981

ERJ5
ER-localized J domain-containing protein 5

1

4

High-throughput

0.407

High

448985

CCH1
Calcium-channel protein CCH1

1

1

High-throughput

0.407

High

449031

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

448936

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.279

Low

448937

CDC11
Cell division control protein 11

1

0

High-throughput

0.279

Low

448949

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.279

Low

448975

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.269

Low

448919

ATE1
Arginyl-tRNA--protein transferase 1

1

0

Small-scale

0.251

Low

448958

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

448956

LDB7
Chromatin structure-remodeling complex protein RSC14

1

0

High-throughput

0.249

Low

448979

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.249

Low

449004

IOC4
ISWI one complex protein 4

1

0

High-throughput

0.249

Low

449024

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025