HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: SH3Y1 (Q96HL8)
SH3 domain-containing YSC84-like protein 1
Gene: SH3YL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006661 - phosphatidylinositol biosynthetic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 342
+	Hs
		203249 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH3G2_HUMAN (135-341): 7.76e-36: 134: 21.15
+	Hs
		203224 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		MYO1E_HUMAN (96-340): 1.48e-33: 133: 19.93
+	Hs
		203248 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH3G1_HUMAN (135-341): 2.5e-34: 131: 20.83
+	Hs
		203262 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		PACN2_HUMAN (182-340): 2.01e-25: 108: 22.50
+	Hs
		203218 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12
+	Rn
		192354 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G2_RAT (135-341): 5.51e-36: 135: 22.12
+	Mm
		88459 D3Z656_MOUSE (1-1573): 0: 1312: 88.66		SH3G2_MOUSE (135-341): 3.08e-36: 135: 22.12
+	Rn
		193638 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G1_RAT (135-341): 5.46e-33: 127: 20.37
+	Hs
		203228 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		ITSN1_HUMAN (169-340): 1.25e-14: 77.2: 12.77
+	Rn
		192356 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G3_RAT (135-341): 3.38e-29: 116: 21.64
+	Mm
		88460 D3Z656_MOUSE (1-1573): 0: 1312: 88.66		SH3G3_MOUSE (135-341): 2.16e-29: 117: 20.67
+	Hs
		203191 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		VINEX_HUMAN (272-342): 6.29e-10: 62.5: 30.14
+	Hs
		166042 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (128-341): 1.08e-15: 80.2: 14.75
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (169-340): 1.25e-14: 77.2: 12.77
+	Dm
		993185 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		GRAP_DROME (288-340): 5.58e-18: 83.2: 49.06
+	Dm
		1137151 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		SH3G3_DROME (200-341): 1.34e-15: 78.6: 22.15
+	Ce
		70018 SYNJ_CAEEL (5-1160): 0: 938: 39.64		SH3GH_CAEEL (139-341): 1.99e-28: 115: 16.74
+	Sc
		797818 INP52_YEAST (8-1175): 0: 828: 25.70		LSB3_YEAST (186-341): 3.38e-23: 101: 23.08
+	Sc
		698140 INP53_YEAST (33-1087): 0: 827: 26.72		YSC84_YEAST (185-342): 1.47e-22: 99.9: 24.05