Protein: PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13)

Gene: PRP22
Organism: Saccharomyces cerevisiae S288C
Interactions: 74
UniProt ID: P24384

Gene Ontology (top 5):
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000390 - spliceosomal complex disassembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664585

PRP8
Pre-mRNA-splicing factor 8

3

8

Small-scale

0.834

High

664599

PRP17
Pre-mRNA-processing factor 17

2

18

Small-scale

0.768

High

664606

CWC22
Pre-mRNA-splicing factor CWC22

2

3

Small-scale

0.768

High

664634

PRP46
Pre-mRNA-splicing factor PRP46

2

17

Small-scale

0.768

High

590177

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

14

Small-scale

0.757

High

664617

CEF1
Pre-mRNA-splicing factor CEF1

5

11

Small-scale

0.720

High

664631

CLF1
Pre-mRNA-splicing factor CLF1

5

20

Small-scale

0.708

High

664580

PRP19
Pre-mRNA-processing factor 19

4

18

Small-scale

0.689

High

664615

SLU7
Pre-mRNA-splicing factor SLU7

3

2

Small-scale

0.653

High

664577

PRP45
Pre-mRNA-processing protein 45

3

8

Small-scale

0.647

High

664575

BUD31
Pre-mRNA-splicing factor BUD31

3

5

Small-scale

0.646

High

664626

RU2A
U2 small nuclear ribonucleoprotein A'

3

7

Small-scale

0.646

High

664627

CWC2
Pre-mRNA-splicing factor CWC2

3

11

Small-scale

0.646

High

664591

DBP7
ATP-dependent RNA helicase DBP7

1

13

Small-scale

0.621

High

664573

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

14

High-throughput

0.618

High

664584

BRR2
Pre-mRNA-splicing helicase BRR2

1

19

High-throughput

0.618

High

664589

NCBP1
Nuclear cap-binding protein complex subunit 1

1

4

High-throughput

0.618

High

664604

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

14

High-throughput

0.618

High

664624

SUB2
ATP-dependent RNA helicase SUB2

1

9

High-throughput

0.618

High

656699

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.614

High

664590

SN114
Pre-mRNA-splicing factor SNU114

2

10

Small-scale

0.595

High

664592

SLT11
Pre-mRNA-splicing factor SLT11

2

3

Small-scale

0.595

High

664593

NTC20
Pre-mRNA-splicing factor NTC20

2

3

Small-scale

0.595

High

664598

MSL1
U2 small nuclear ribonucleoprotein B''

2

20

Small-scale

0.595

High

664605

SYF2
Pre-mRNA-splicing factor SYF2

2

3

Small-scale

0.595

High

664616

CWC21
Pre-mRNA-splicing factor CWC21

2

2

Small-scale

0.595

High

664618

CWC15
Pre-mRNA-splicing factor CWC15

2

2

Small-scale

0.595

High

664620

SYF1
Pre-mRNA-splicing factor SYF1

2

20

Small-scale

0.595

High

664622

SN309
Pre-mRNA-splicing factor SNT309

2

2

Small-scale

0.595

High

664635

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.586

High

664625

NCBP2
Nuclear cap-binding protein subunit 2

2

7

High-throughput

0.584

High

664586

PRP18
Pre-mRNA-splicing factor 18

2

0

Small-scale

0.569

High

664609

TEX1
Protein TEX1

1

11

High-throughput

0.553

High

664596

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

664630

BBP
Branchpoint-bridging protein

1

5

High-throughput

0.508

High

664595

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

8

Small-scale

0.501

High

664597

RUXG
Small nuclear ribonucleoprotein G

1

5

Small-scale

0.501

High

664600

SMD3
Small nuclear ribonucleoprotein Sm D3

1

7

Small-scale

0.501

High

664611

RUXF
Small nuclear ribonucleoprotein F

1

6

Small-scale

0.501

High

664613

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

Small-scale

0.501

High

664623

SMD2
Small nuclear ribonucleoprotein Sm D2

1

4

Small-scale

0.501

High

664633

RUXE
Small nuclear ribonucleoprotein E

1

2

Small-scale

0.501

High

638045

ISY1
Pre-mRNA-splicing factor ISY1

1

4

High-throughput

0.479

High

664629

YRA1
RNA annealing protein YRA1

1

6

High-throughput

0.479

High

664636

RRP12
Ribosomal RNA-processing protein 12

1

4

Small-scale

0.479

High

392271

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.445

High

523125

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

525975

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

543887

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

664576

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

664582

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

664583

HSP79
Heat shock protein homolog SSE2

1

10

High-throughput

0.445

High

664587

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

664601

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

150150

THP2
THO complex subunit THP2

1

1

High-throughput

0.437

High

605871

HPR1
THO complex subunit HPR1

1

1

High-throughput

0.437

High

664579

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.437

High

664581

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.437

High

664588

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.437

High

664603

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

3

High-throughput

0.437

High

664608

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.437

High

664612

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

9

High-throughput

0.437

High

664628

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.437

High

664594

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.426

High

664632

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

664574

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.269

Low

664607

SOK2
Protein SOK2

1

0

High-throughput

0.269

Low

664614

RPM2
Ribonuclease P protein component, mitochondrial

1

0

Small-scale

0.261

Low

664578

MPI
Mannose-6-phosphate isomerase

1

0

Small-scale

0.251

Low

664602

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

664619

CSN9
COP9 signalosome complex subunit 9

1

0

Small-scale

0.249

Low

664621

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

664610

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025