HitPredict

Interactor 1: SYNJ1 (O43426)
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
Gene: SYNJ1

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1573 Hs			1 1292
+	Hs
		203208 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		203224 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		203228 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		203192 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		203230 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		SH319_HUMAN (793-851): 9.71e-11: 68.4: 37.29
+	Hs
		203191 SYNJ1_HUMAN (1-1573): 0: 1356: 100.00		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59
+	Rn
		192744 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SRBS2_RAT (508-926): 5.66e-14: 79.4: 15.40
+	Rn
		193638 SYNJ1_RAT (1-1573): 0: 1317: 88.27		SH3G1_RAT (780-926): 2.11e-14: 78.4: 26.14
+	Hs
		166030 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		166049 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		166056 SYNJ2_HUMAN (1-1418): 0: 1118: 41.56		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Dm
		112574 Q5U0V7_DROME (1-1130): 0: 1048: 48.47		M9ND00_DROME (1091-1292): 1.63e-09: 64.8: 12.87
+	Ce
		104677 SYNJ_CAEEL (5-1160): 0: 938: 39.64		SRBS1_CAEEL (268-848): 2.47e-13: 77.3: 17.04
+	Ce
		105207 SYNJ_CAEEL (5-1160): 0: 938: 39.64		G5ECK4_CAEEL (859-926): 4.59e-12: 73: 36.77
+	Ce
		105281 SYNJ_CAEEL (5-1160): 0: 938: 39.64		Q9U2T9_CAEEL (1077-1290): 7.67e-10: 65.6: 12.61
+	Mm
		1143295 SHIP1_MOUSE (505-1251): 6.64e-154: 502: 20.90		PLCG1_MOUSE (394-868): 2.19e-42: 171: 12.47
+	Hs
		557759 SHIP1_HUMAN (505-1301): 1.21e-138: 461: 21.40		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		968139 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		968134 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		298971 OCRL_HUMAN (502-978): 5.31e-125: 415: 27.52		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74