Interactor 1: MED7 (O43513)
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
Gene: MED7

Interactor 2: MED31 (Q9Y3C7)
Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)
Gene: MED31

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.955

The method score is based on:

Property Details
Experiments 35271311, 26186194, 28514442, 24981860, 33961781, 20211142
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med31~Med7
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
and 6 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 233
Hs

1 131
+ Dm
+ At
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024