HitPredict

Interactor 1: FRS3 (O43559)
Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)
Gene: FRS3

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23279575
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 492 Hs			1 639
+	Hs
		207363 FRS3_HUMAN (1-492): 0: 703: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		924725 FRS2_HUMAN (1-492): 0: 598: 45.98		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141149 FRS2_MOUSE (1-492): 0: 589: 46.36		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Rn
		88884 D4A244_RAT (1-492): 0: 586: 46.55		GRB2_RAT (112-328): 1.9e-40: 148: 18.27
+	Hs
		209149 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		223011 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		NCK2_MOUSE (2-361): 1.08e-58: 203: 16.58
+	Hs
		924816 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924665 DOK3_HUMAN (20-281): 5.12e-67: 225: 19.20		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		956520 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557780 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Mm
		223005 DOK2_MOUSE (20-290): 2.38e-32: 129: 21.79		NCK2_MOUSE (2-361): 1.08e-58: 203: 16.58
+	Hs
		208960 DOK2_HUMAN (20-245): 6.89e-30: 122: 23.63		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		1141171 DOK3_MOUSE (19-281): 3.72e-48: 173: 20.85		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Mm
		956524 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		NCK1_MOUSE (113-378): 6.4e-21: 97.3: 14.24
+	Mm
		250957 DOK2_MOUSE (20-290): 2.38e-32: 129: 21.79		NCK1_MOUSE (113-378): 6.4e-21: 97.3: 14.24
+	Hs
		235041 DOK2_HUMAN (20-245): 6.89e-30: 122: 23.63		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24