Protein: CD2B2
CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K)

Gene: CD2B2, CD2BP2
Organism: Homo sapiens
Interactions: 225
UniProt ID: O95400

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0001650 - fibrillar center
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005682 - U5 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335815

TXN4A
Thioredoxin-like protein 4A

6

0

Small-scale

0.904

High

335772

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

11

4

Small-scale

0.762

High

321394

PRP6
Pre-mRNA-processing factor 6

11

2

Small-scale

0.761

High

335863

PRP8
Pre-mRNA-processing-splicing factor 8

10

2

High-throughput

0.754

High

335895

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

8

2

High-throughput

0.750

High

335909

DDX23
Probable ATP-dependent RNA helicase DDX23

7

3

High-throughput

0.747

High

289391

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

6

6

High-throughput

0.735

High

335844

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

6

1

High-throughput

0.735

High

335811

RSMN
Small nuclear ribonucleoprotein-associated protein N

5

4

Small-scale

0.717

High

335801

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

2

Small-scale

0.714

High

335764

CD2
T-cell surface antigen CD2

6

0

Small-scale

0.713

High

335867

ACD11
Acyl-CoA dehydrogenase family member 11

6

0

High-throughput

0.704

High

335805

RUXF
Small nuclear ribonucleoprotein F

4

2

High-throughput

0.702

High

335807

SMD1
Small nuclear ribonucleoprotein Sm D1

4

3

High-throughput

0.699

High

335888

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

4

2

High-throughput

0.699

High

335856

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

5

0

High-throughput

0.690

High

335788

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

2

High-throughput

0.677

High

335804

RUXE
Small nuclear ribonucleoprotein E

4

0

High-throughput

0.670

High

335857

EAPP
E2F-associated phosphoprotein

4

0

High-throughput

0.670

High

335945

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

0

High-throughput

0.664

High

335806

RUXG
Small nuclear ribonucleoprotein G

3

6

High-throughput

0.662

High

335854

SMU1
WD40 repeat-containing protein SMU1

3

2

High-throughput

0.650

High

335780

SFPQ
Splicing factor, proline- and glutamine-rich

3

2

Small-scale

0.647

High

335808

SMD2
Small nuclear ribonucleoprotein Sm D2

3

0

High-throughput

0.646

High

212123

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

3

0

High-throughput

0.638

High

335840

NAA30
N-alpha-acetyltransferase 30

3

0

High-throughput

0.638

High

335864

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

3

High-throughput

0.628

High

335940

WBP11
WW domain-binding protein 11

2

1

Small-scale

0.620

High

335768

SNRPA
U1 small nuclear ribonucleoprotein A

2

2

Small-scale

0.619

High

209177

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

2

3

High-throughput

0.611

High

335809

SMD3
Small nuclear ribonucleoprotein Sm D3

2

3

High-throughput

0.611

High

335851

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.611

High

335907

RBM42
RNA-binding protein 42

2

1

High-throughput

0.611

High

335941

AAR2
Protein AAR2 homolog

2

1

High-throughput

0.611

High

335855

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

1

High-throughput

0.602

High

271788

OBSL1
Obscurin-like protein 1

2

0

High-throughput

0.602

High

335818

EWS
RNA-binding protein EWS

2

1

High-throughput

0.601

High

335753

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.586

High

215005

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.585

High

335797

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.585

High

335833

SNW1
SNW domain-containing protein 1

2

0

High-throughput

0.585

High

335923

TLS1
Splicing factor C9orf78

2

0

High-throughput

0.585

High

295968

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.580

High

335849

SF3B4
Splicing factor 3B subunit 4

2

0

Small-scale

0.569

High

259255

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

335767

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

0

High-throughput

0.559

High

335763

FYN
Tyrosine-protein kinase Fyn

2

0

High-throughput

0.547

High

335881

ARH40
Rho guanine nucleotide exchange factor 40

2

0

High-throughput

0.547

High

335774

GCFC2
Intron Large complex component GCFC2

1

1

High-throughput

0.536

High

335837

RBM39
RNA-binding protein 39

1

2

High-throughput

0.536

High

335843

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

335872

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.536

High

335921

RBM22
Pre-mRNA-splicing factor RBM22

1

1

High-throughput

0.536

High

335922

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

335939

TR150
Thyroid hormone receptor-associated protein 3

1

2

High-throughput

0.536

High

335944

PAXB1
PAX3- and PAX7-binding protein 1

1

1

High-throughput

0.536

High

335870

AKNA
Microtubule organization protein AKNA

1

0

Small-scale

0.531

High

335946

MAGD1
Melanoma-associated antigen D1

1

0

Small-scale

0.531

High

335887

PSMF1
Proteasome inhibitor PI31 subunit

1

0

Small-scale

0.529

High

335812

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

335835

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.515

High

335931

PUF60
Poly(U)-binding-splicing factor PUF60

1

2

High-throughput

0.515

High

335757

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

335769

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

335785

NKTR
NK-tumor recognition protein

1

0

High-throughput

0.513

High

335792

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.513

High

335816

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.513

High

335825

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

335834

CUL3
Cullin-3

1

0

High-throughput

0.513

High

335836

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

335841

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.513

High

335883

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.513

High

335899

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.513

High

335905

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

335912

PININ
Pinin

1

0

High-throughput

0.513

High

335925

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.513

High

335926

POLK
DNA polymerase kappa

1

0

High-throughput

0.513

High

185315

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

335822

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

Small-scale

0.501

High

335846

Q15182
Small nuclear ribonucleoprotein-associated protein

1

4

Small-scale

0.501

High

335852

SF01
Splicing factor 1

1

1

Small-scale

0.501

High

335858

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.501

High

228134

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.493

High

335765

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.493

High

335793

KHK
Ketohexokinase

1

0

High-throughput

0.493

High

335838

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.493

High

335873

CRERF
CREB3 regulatory factor

1

0

High-throughput

0.493

High

335894

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.493

High

335876

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.481

High

215888

SYNJ1
Synaptojanin-1

1

0

Small-scale

0.480

High

335791

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.480

High

335919

RBM12
RNA-binding protein 12

1

0

Small-scale

0.480

High

207394

DHX15
ATP-dependent RNA helicase DHX15

1

2

High-throughput

0.479

High

222411

PLRG1
Pleiotropic regulator 1

1

2

High-throughput

0.479

High

225237

HTSF1
17S U2 SnRNP complex component HTATSF1

1

2

High-throughput

0.479

High

253572

IMA7
Importin subunit alpha-7

1

1

High-throughput

0.479

High

335756

ECD
Protein ecdysoneless homolog

1

1

High-throughput

0.479

High

335760

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

335766

RU2B
U2 small nuclear ribonucleoprotein B''

1

2

High-throughput

0.479

High

335770

RU2A
U2 small nuclear ribonucleoprotein A'

1

2

High-throughput

0.479

High

335773

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

335778

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

High-throughput

0.479

High

335795

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.479

High

335802

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

High-throughput

0.479

High

335820

TLE3
Transducin-like enhancer protein 3

1

4

High-throughput

0.479

High

335821

SRS11
Serine/arginine-rich splicing factor 11

1

1

High-throughput

0.479

High

335823

SRSF1
Serine/arginine-rich splicing factor 1

1

2

High-throughput

0.479

High

335824

SRSF4
Serine/arginine-rich splicing factor 4

1

2

High-throughput

0.479

High

335829

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

335830

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.479

High

335839

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.479

High

335847

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.479

High

335850

SF3A2
Splicing factor 3A subunit 2

1

1

High-throughput

0.479

High

335868

DDX46
Probable ATP-dependent RNA helicase DDX46

1

3

High-throughput

0.479

High

335871

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.479

High

335874

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

335877

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

335878

NEDD1
Protein NEDD1

1

4

High-throughput

0.479

High

335886

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.479

High

335891

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

335893

GCP3
Gamma-tubulin complex component 3

1

4

High-throughput

0.479

High

335901

GCP6
Gamma-tubulin complex component 6

1

4

High-throughput

0.479

High

335902

GCP5
Gamma-tubulin complex component 5

1

4

High-throughput

0.479

High

335903

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

335906

GCP2
Gamma-tubulin complex component 2

1

4

High-throughput

0.479

High

335908

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.479

High

335928

GCP4
Gamma-tubulin complex component 4

1

4

High-throughput

0.479

High

335929

DDX20
Probable ATP-dependent RNA helicase DDX20

1

4

High-throughput

0.479

High

335936

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

335937

PRP19
Pre-mRNA-processing factor 19

1

3

High-throughput

0.479

High

335942

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

3

High-throughput

0.479

High

335947

RA54B
DNA repair and recombination protein RAD54B

1

1

High-throughput

0.479

High

335754

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.460

High

335892

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.460

High

335911

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.460

High

128694

MEN1
Menin

1

0

High-throughput

0.458

High

134511

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

137896

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

175558

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.458

High

245046

AQR
RNA helicase aquarius

1

0

High-throughput

0.458

High

285550

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

285757

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.458

High

292413

PALM
Paralemmin-1

1

0

High-throughput

0.458

High

292981

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

322888

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.458

High

324373

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

326172

FSBP
Fibrinogen silencer-binding protein

1

0

High-throughput

0.458

High

335409

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

335755

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

335758

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

335759

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.458

High

335762

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

335771

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

335776

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

335777

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

335781

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.458

High

335782

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

335783

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

335784

RBL1
Retinoblastoma-like protein 1

1

0

High-throughput

0.458

High

335787

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

335789

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

335790

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

335794

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

335796

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

335798

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

335799

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

335800

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

335803

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

335810

H4
Histone H4

1

0

High-throughput

0.458

High

335817

VIGLN
Vigilin

1

0

High-throughput

0.458

High

335819

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

335826

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

335827

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

335828

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

335831

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.458

High

335832

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.458

High

335842

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

335845

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

335848

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.458

High

335853

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

335861

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.458

High

335862

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

335865

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

335866

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.458

High

335869

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.458

High

335879

SP7
Transcription factor Sp7

1

0

High-throughput

0.458

High

335880

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

335882

PNISR
Arginine/serine-rich protein PNISR

1

0

High-throughput

0.458

High

335884

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.458

High

335885

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

335889

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

335896

CDCA5
Sororin

1

0

High-throughput

0.458

High

335898

TOE1
Target of EGR1 protein 1

1

0

High-throughput

0.458

High

335900

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

335904

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

335910

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

335913

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

335914

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

335916

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

0

High-throughput

0.458

High

335917

ANLN
Anillin

1

0

High-throughput

0.458

High

335918

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

335920

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

335924

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.458

High

335927

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

335932

XPO7
Exportin-7

1

0

High-throughput

0.458

High

335933

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.458

High

335934

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.458

High

335938

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

71549

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

335860

PR38B
Pre-mRNA-splicing factor 38B

1

1

High-throughput

0.437

High

335786

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

335897

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

335930

ZNHI2
Zinc finger HIT domain-containing protein 2

4

0

High-throughput

0.361

High

335875

KLH36
Kelch-like protein 36

3

0

High-throughput

0.347

High

335779

ACM3
Muscarinic acetylcholine receptor M3

1

0

High-throughput

0.282

High

335775

BPI
Bactericidal permeability-increasing protein

1

0

High-throughput

0.279

Low

335890

K1143
Uncharacterized protein KIAA1143

1

0

High-throughput

0.279

Low

335813

DCD
Dermcidin

1

0

High-throughput

0.269

Low

335761

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

335814

CRUM1
Protein crumbs homolog 1

1

0

High-throughput

0.249

Low

335859

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

335915

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.249

Low

335935

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

335943

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025