Protein: PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)

Gene: PRP16, DHX38
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q92620

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1365838

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

3

12

High-throughput

0.861

High

1365867

FBW1A
F-box/WD repeat-containing protein 1A

2

12

High-throughput

0.811

High

238928

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

2

15

High-throughput

0.808

High

1241712

PRP8
Pre-mRNA-processing-splicing factor 8

2

8

High-throughput

0.754

High

1023134

RBM10
RNA-binding protein 10

1

14

High-throughput

0.740

High

1365835

GPKOW
G-patch domain and KOW motifs-containing protein

1

3

High-throughput

0.740

High

1311819

DHX40
Probable ATP-dependent RNA helicase DHX40

2

15

High-throughput

0.737

High

335888

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

4

2

High-throughput

0.699

High

952007

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

4

3

Small-scale

0.697

High

1214066

IFT1B
Protein IFIT1 homolog B

1

5

High-throughput

0.691

High

1365856

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

4

0

High-throughput

0.670

High

1365843

NUDC1
NudC domain-containing protein 1

3

6

High-throughput

0.667

High

181010

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

1

High-throughput

0.667

High

1234606

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

3

1

High-throughput

0.662

High

1365857

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

2

2

High-throughput

0.631

High

1239640

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

7

High-throughput

0.628

High

1145304

RNPS1
RNA-binding protein with serine-rich domain 1

2

15

High-throughput

0.621

High

289634

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

Small-scale

0.621

High

346138

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.618

High

1088482

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.618

High

1128074

DHX8
ATP-dependent RNA helicase DHX8

1

16

High-throughput

0.618

High

1365846

DDX23
Probable ATP-dependent RNA helicase DDX23

1

15

High-throughput

0.618

High

1365870

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.618

High

302122

CDKL5
Cyclin-dependent kinase-like 5

2

6

High-throughput

0.611

High

1365866

AURKC
Aurora kinase C

2

5

High-throughput

0.611

High

1208190

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

2

1

High-throughput

0.601

High

129299

MEN1
Menin

2

4

High-throughput

0.584

High

372725

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

386042

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

7

High-throughput

0.584

High

1365868

AAR2
Protein AAR2 homolog

2

2

High-throughput

0.584

High

321612

PRP6
Pre-mRNA-processing factor 6

1

16

High-throughput

0.575

High

396630

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

530152

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.571

High

835720

KPCI
Protein kinase C iota type

2

3

High-throughput

0.571

High

1254880

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

997903

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.550

High

286489

WBP4
WW domain-binding protein 4

1

9

Small-scale

0.541

High

1016359

SERF2
Small EDRK-rich factor 2

1

1

High-throughput

0.536

High

1059908

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

High-throughput

0.536

High

1113881

CUL3
Cullin-3

1

13

High-throughput

0.536

High

1117621

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.536

High

1199442

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

13

High-throughput

0.536

High

1200222

LBH
Protein LBH

1

1

High-throughput

0.536

High

1294471

VRK2
Serine/threonine-protein kinase VRK2

1

4

High-throughput

0.536

High

1365834

EZH1
Histone-lysine N-methyltransferase EZH1

1

7

High-throughput

0.536

High

1365842

BIRC8
Baculoviral IAP repeat-containing protein 8

1

7

High-throughput

0.536

High

1365859

PEN2
Gamma-secretase subunit PEN-2

1

1

High-throughput

0.536

High

1361069

ASB12
Ankyrin repeat and SOCS box protein 12

1

0

High-throughput

0.517

High

831155

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

948569

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1023586

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1218516

ZN691
Zinc finger protein 691

1

0

High-throughput

0.513

High

1251732

CERS6
Ceramide synthase 6

1

0

High-throughput

0.513

High

1365840

RUSF1
RUS family member 1

1

0

High-throughput

0.513

High

935583

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.508

High

566778

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.493

High

302195

NEBL
Nebulette

1

1

High-throughput

0.489

High

1246095

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.489

High

1365854

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.489

High

1365860

GPC5D
G-protein coupled receptor family C group 5 member D

1

1

High-throughput

0.489

High

1028690

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.486

High

130563

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

157691

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

191030

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

242462

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

260236

BRD4
Bromodomain-containing protein 4

1

16

High-throughput

0.479

High

363656

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

412361

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

414323

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

558300

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

559439

XRCC5
X-ray repair cross-complementing protein 5

1

5

High-throughput

0.479

High

589302

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

674275

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

696092

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

714309

PML
Protein PML

1

15

High-throughput

0.479

High

768789

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

794560

RBMX
RNA-binding motif protein, X chromosome

1

8

High-throughput

0.479

High

799346

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.479

High

800016

COIL
Coilin

1

3

High-throughput

0.479

High

879318

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

897353

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.479

High

914016

CHIO
Beta-chimaerin

1

1

High-throughput

0.479

High

980071

H4
Histone H4

1

5

High-throughput

0.479

High

980975

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

996268

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

998621

H31
Histone H3.1

1

5

High-throughput

0.479

High

1067557

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

1088933

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1097458

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

1100181

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1107067

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1127048

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1138454

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

10

High-throughput

0.479

High

1141242

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.479

High

1153009

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.479

High

1161582

IF16
Gamma-interferon-inducible protein 16

1

7

High-throughput

0.479

High

1201271

EAPP
E2F-associated phosphoprotein

1

2

High-throughput

0.479

High

1276571

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1314336

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1329780

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1365833

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1365844

CDC5L
Cell division cycle 5-like protein

1

11

High-throughput

0.479

High

1365851

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1365852

ANLN
Anillin

1

4

High-throughput

0.479

High

1365853

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

1365863

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1365865

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

1365871

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

2

High-throughput

0.479

High

1289500

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1365837

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.458

High

1365847

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

719573

NKTR
NK-tumor recognition protein

1

4

High-throughput

0.445

High

1338156

PPHLN
Periphilin-1

1

1

High-throughput

0.445

High

1356386

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

5

High-throughput

0.445

High

1365836

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

High-throughput

0.445

High

1365845

BUD13
BUD13 homolog

1

7

High-throughput

0.445

High

1365858

BCLF1
Bcl-2-associated transcription factor 1

1

8

High-throughput

0.445

High

1365869

RBMX2
RNA-binding motif protein, X-linked 2

1

11

High-throughput

0.445

High

1365841

SNX27
Sorting nexin-27

1

1

High-throughput

0.437

High

1365849

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1365850

ANTR1
Anthrax toxin receptor 1

1

1

Small-scale

0.437

High

1365861

VSX1
Visual system homeobox 1

1

0

High-throughput

0.426

High

1340182

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

3

High-throughput

0.407

High

1365862

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

2

High-throughput

0.407

High

1322706

F177A
Protein FAM177A1

2

0

High-throughput

0.318

High

1365839

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1365848

F107B
Protein FAM107B

1

0

High-throughput

0.279

Low

1365855

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1365864

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025