HitPredict

Interactor 1: RGS14 (O43566)
Regulator of G-protein signaling 14 (RGS14)
Gene: RGS14

Interactor 2: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10926822
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RBD~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 566 Hs			1 184
+	Hs
		207508 RGS14_HUMAN (1-566): 0: 656: 100.00		RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43
+	Hs
		207504 RGS14_HUMAN (1-566): 0: 656: 100.00		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Mm
		918978 RGS14_MOUSE (1-545): 0: 594: 87.93		RAB1A_MOUSE (4-183): 2.18e-73: 221: 31.49
+	Rn
		139845 RGS12_RAT (16-552): 8.05e-168: 514: 37.46		RASH_RAT (1-180): 7.38e-55: 173: 55.00
+	Hs
		158596 RGS12_HUMAN (3-562): 7.98e-167: 513: 36.61		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Dm
		442972 RGS_DROME (7-514): 7.23e-131: 418: 28.41		RAP1_DROME (1-166): 4.93e-83: 244: 89.76
+	Dm
		442973 Q9VCX2_DROME (7-514): 1.19e-126: 401: 27.86		RAP1_DROME (1-166): 4.93e-83: 244: 89.76
+	Dm
		332220 RGS_DROME (7-514): 7.23e-131: 418: 28.41		O96692_DROME (1-181): 4.72e-60: 186: 56.91
+	Dm
		443010 RGS_DROME (7-514): 7.23e-131: 418: 28.41		RAS1_DROME (1-178): 8.95e-54: 171: 52.81
+	Dm
		332221 Q9VCX2_DROME (7-514): 1.19e-126: 401: 27.86		O96692_DROME (1-181): 4.72e-60: 186: 56.91
+	Dm
		443011 Q9VCX2_DROME (7-514): 1.19e-126: 401: 27.86		RAS1_DROME (1-178): 8.95e-54: 171: 52.81
+	Hs
		782023 RGS2_HUMAN (53-182): 1.45e-17: 83.6: 37.41		RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11