HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0072686 - mitotic spindle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1193
+	Hs
		254479 CUL3_HUMAN (1-768): 0: 951: 100.00		ROCK2_HUMAN (526-1193): 1.76e-21: 103: 11.92
+	Hs
		551697 CUL3_HUMAN (1-768): 0: 951: 100.00		DESP_HUMAN (501-1190): 6.44e-19: 95.8: 11.43
+	Hs
		1041611 CUL3_HUMAN (1-768): 0: 951: 100.00		EEA1_HUMAN (691-1193): 8.44e-18: 91.8: 12.35
+	Hs
		1035169 CUL3_HUMAN (1-768): 0: 951: 100.00		ROCK1_HUMAN (546-1186): 1.44e-17: 90.8: 14.97
+	Hs
		1042182 CUL3_HUMAN (1-768): 0: 951: 100.00		MY18A_HUMAN (692-1192): 6.2e-16: 85.8: 13.78
+	Hs
		1041911 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		1041614 CUL3_HUMAN (1-768): 0: 951: 100.00		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		725157 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		724816 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		148780 CUL3_HUMAN (1-768): 0: 951: 100.00		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		1035170 CUL4A_HUMAN (10-768): 0: 791: 38.32		ROCK1_HUMAN (546-1186): 1.44e-17: 90.8: 14.97
+	Hs
		1043487 CUL4B_HUMAN (5-768): 0: 779: 36.77		MY18A_HUMAN (692-1192): 6.2e-16: 85.8: 13.78
+	Hs
		725158 CUL4A_HUMAN (10-768): 0: 791: 38.32		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		502913 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH3_HUMAN (173-1134): 9.39e-30: 131: 11.22
+	Hs
		725156 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		724815 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		551696 CUL2_HUMAN (30-768): 0: 672: 26.17		DESP_HUMAN (501-1190): 6.44e-19: 95.8: 11.43