HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	18539162
Identification Methods	unspecified method, x-ray crystallography, pull down, nuclear magnetic resonance
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin, SH3_9~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 685
+	Hs
		476483 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475368 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475816 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		411563 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475592 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476167 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475292 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		557653 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		70590 B2RR82_MOUSE (3-305): 1.08e-27: 117: 15.64		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		923946 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		1144043 FYN_RAT (7-137): 2.1e-23: 103: 20.30		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Rn
		1144206 FGR_RAT (6-145): 1.71e-22: 100: 20.42		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		477062 ITSN1_MOUSE (6-70): 1.15e-18: 90.1: 29.23		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		924996 GRB2_RAT (3-61): 2.24e-18: 84.7: 28.81		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		397850 BLK_HUMAN (7-204): 3.35e-19: 91: 19.80		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		474986 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70