HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15117958
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 822
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		208993 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		209018 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA4_HUMAN (3-783): 0: 620: 19.44
+	Hs
		557643 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHA5_HUMAN (3-791): 0: 639: 19.15
+	Hs
		557644 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHB1_HUMAN (4-798): 0: 639: 17.57
+	Hs
		208997 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA8_HUMAN (3-819): 0: 603: 19.35
+	Hs
		208996 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA2_HUMAN (3-819): 0: 583: 18.68
+	Hs
		209065 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70
+	Hs
		209063 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08
+	Hs
		208998 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		UFO_HUMAN (8-815): 1.07e-155: 479: 21.98
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (111-762): 4.27e-163: 496: 23.89
+	Hs
		557707 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70
+	Hs
		557705 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96
+	Hs
		208976 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		RET_HUMAN (384-774): 2.63e-98: 332: 45.77
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (384-774): 2.63e-98: 332: 45.77
+	Hs
		557625 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR2_HUMAN (43-343): 3.9e-15: 82.1: 16.26
+	Hs
		557624 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR3_HUMAN (31-128): 2.94e-10: 66.3: 21.15
+	Ce
		105201 CSK1_CAEEL (148-379): 2.74e-32: 129: 19.36		EGL15_CAEEL (41-249): 3.81e-19: 94.8: 18.30