Protein: FADS2
Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)

Gene: FADS2
Organism: Homo sapiens
Interactions: 78
UniProt ID: O95864

Gene Ontology (top 5):
GO:0002538 - arachidonate metabolite production involved in inflammatory response
GO:0004768 - stearoyl-CoA 9-desaturase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350268

FADS3
Fatty acid desaturase 3

1

13

High-throughput

0.691

High

350267

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.618

High

350260

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.586

High

350234

K1H1
Keratin, type I cuticular Ha1

2

1

High-throughput

0.553

High

350239

K1C40
Keratin, type I cytoskeletal 40

2

1

High-throughput

0.553

High

350210

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.536

High

350223

PSN1
Presenilin-1

1

1

High-throughput

0.536

High

170599

CLGN
Calmegin

1

1

High-throughput

0.515

High

350259

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

350206

APOB
Apolipoprotein B-100

1

0

High-throughput

0.493

High

48477

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.479

High

133718

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

173821

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

217674

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

240407

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

318553

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.479

High

350207

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

350208

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

350209

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

350213

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

350214

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

350219

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

5

Small-scale

0.479

High

350224

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.479

High

350225

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.479

High

350228

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

350230

VIGLN
Vigilin

1

1

High-throughput

0.479

High

350233

CUL3
Cullin-3

1

1

High-throughput

0.479

High

350235

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

350252

RN139
E3 ubiquitin-protein ligase RNF139

1

2

High-throughput

0.479

High

350253

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

350257

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

350258

DERL1
Derlin-1

1

1

High-throughput

0.479

High

350261

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

350265

AMFR
E3 ubiquitin-protein ligase AMFR

1

3

High-throughput

0.479

High

350266

ALK
ALK tyrosine kinase receptor

1

3

Small-scale

0.479

High

350217

CCNF
Cyclin-F

1

1

High-throughput

0.470

High

350212

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

279092

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

350203

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

350216

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

350218

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

350226

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.458

High

350232

CLN3
Battenin

1

0

Small-scale

0.458

High

350241

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

350250

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

255952

S19A2
Thiamine transporter 1

1

4

High-throughput

0.445

High

350215

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

2

High-throughput

0.445

High

350227

CD81
CD81 antigen

1

4

High-throughput

0.445

High

350236

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.445

High

350238

S22AA
Solute carrier family 22 member 10

1

4

High-throughput

0.445

High

350247

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.445

High

350211

ATX1L
Ataxin-1-like

1

1

High-throughput

0.439

High

350244

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.439

High

47940

RBM47
RNA-binding protein 47

1

1

High-throughput

0.437

High

350204

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

350220

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

350221

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

350229

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

350240

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

350242

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

350249

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

350255

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

350264

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

350245

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.426

High

350246

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

350248

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

350237

LELP1
Late cornified envelope-like proline-rich protein 1

1

0

High-throughput

0.269

Low

350251

CC110
Coiled-coil domain-containing protein 110

1

0

High-throughput

0.269

Low

350254

SPDLY
Protein Spindly

1

0

High-throughput

0.269

Low

350262

PANK3
Pantothenate kinase 3

1

0

High-throughput

0.269

Low

350263

GPBL1
Vasculin-like protein 1

1

0

High-throughput

0.269

Low

453

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

350231

GRSF1
G-rich sequence factor 1

1

0

Small-scale

0.251

Low

350205

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

350222

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

350243

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

869

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

350256

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025