HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007172 - signal complex assembly GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 591
+	Hs
		557639 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		782755 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		412085 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		442793 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		209005 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97
+	Hs
		823358 BLK_HUMAN (7-204): 3.35e-19: 91: 19.80		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		411641 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Mm
		403454 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		823365 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		522857 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		200163 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91
+	Hs
		442845 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		300996 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		ABLM3_HUMAN (416-590): 1.41e-40: 158: 29.03
+	Hs
		782788 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Ce
		107567 SRC2_CAEEL (1-202): 6.89e-21: 96: 16.75		G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00
+	Hs
		924889 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		111447 J3QRU1_HUMAN (6-120): 6.72e-16: 81.2: 23.08		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		442827 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		254384 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		LDB3_HUMAN (474-590): 4.47e-13: 74.3: 33.33
+	Hs
		150552 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32