HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 192
+	Mm
		643072 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71
+	Hs
		655307 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		412123 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545215 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		655467 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		411980 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		129190 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		655294 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		655316 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		129259 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		655295 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		655297 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		412113 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		129260 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		412115 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		129262 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436167 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564419 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		411948 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		129193 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49