HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: NHS (Q6T4R5)
Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)
Gene: NHS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1651
+	Hs
		209070 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NHSL2_HUMAN (366-1545): 1.39e-37: 157: 20.51
+	Hs
		557708 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NHSL2_HUMAN (366-1545): 1.39e-37: 157: 20.51
+	Hs
		209076 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NHSL1_HUMAN (186-1650): 2.62e-29: 130: 16.92
+	Hs
		557712 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NHSL1_HUMAN (186-1650): 2.62e-29: 130: 16.92
+	Hs
		557777 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINT_HUMAN (137-1650): 3.44e-26: 120: 9.28
+	Hs
		557660 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ANK2_HUMAN (891-1627): 3.99e-09: 64: 15.52
+	Hs
		257713 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		ANR17_HUMAN (444-1418): 4.69e-41: 169: 11.64
+	Hs
		924473 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MAP1A_HUMAN (4-1650): 1.9e-34: 147: 8.38
+	Hs
		411582 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MUC1_HUMAN (9-990): 2.46e-31: 136: 9.62
+	Hs
		655449 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		MINT_HUMAN (137-1650): 3.44e-26: 120: 9.28
+	Hs
		554292 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MUC1_HUMAN (9-990): 2.46e-31: 136: 9.62
+	Hs
		782820 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		CIC_HUMAN (32-1650): 2.13e-17: 91.1: 9.06
+	Hs
		522749 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		MUC1_HUMAN (9-990): 2.46e-31: 136: 9.62
+	Hs
		924808 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MINT_HUMAN (137-1650): 3.44e-26: 120: 9.28
+	Hs
		1056926 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		MDC1_HUMAN (55-1196): 1.34e-24: 114: 10.45
+	Hs
		924760 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PRG4_HUMAN (1008-1651): 1.03e-23: 111: 9.20
+	Hs
		523118 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		CIC_HUMAN (32-1650): 2.13e-17: 91.1: 9.06
+	Hs
		1285227 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		SRRM2_HUMAN (862-1609): 8.37e-11: 69.6: 8.69
+	Hs
		924484 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		ANK2_HUMAN (891-1627): 3.99e-09: 64: 15.52