HitPredict

Interactor 1: PLRG1 (O43660)
Pleiotropic regulator 1
Gene: PLRG1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26949739, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Hs			1 768
+	Hs
		1042655 NLE1_HUMAN (49-357): 5.8e-65: 220: 17.74		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		903207 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		CUL3_HUMAN (1-768): 0: 951: 100.00
+	At
		1114752 PRL1_ARATH (23-506): 8.31e-102: 316: 43.30		CUL4_ARATH (8-768): 0: 744: 38.61
+	Hs
		1043562 TBL1R_HUMAN (191-514): 2.22e-85: 274: 19.20		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		245601 TBL1X_HUMAN (148-514): 2.87e-83: 270: 18.37		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043319 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043157 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043509 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903208 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		792982 LIS1_HUMAN (38-318): 4.42e-54: 189: 17.55		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043085 WDR5B_HUMAN (322-514): 6.62e-53: 183: 21.54		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		903209 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043441 WDR5B_HUMAN (322-514): 6.62e-53: 183: 21.54		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041292 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1043499 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903206 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Mm
		1257398 FBXW7_MOUSE (315-514): 5.46e-43: 164: 21.78		CUL1_MOUSE (17-768): 0: 709: 30.53
+	Hs
		1041133 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1274084 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Sp
		142917 POF11_SCHPO (194-414): 6.04e-18: 88.6: 28.89		CUL1_SCHPO (15-768): 0: 672: 28.29