HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.848

Property	Details
Experiments	15827961, 16839418, 10553045
Identification Methods	pull down, coimmunoprecipitation, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 389
+	Mm
		411934 LCK_MOUSE (1-509): 0: 657: 96.86		SH22A_MOUSE (1-354): 3.17e-78: 247: 62.53
+	Hs
		411580 LCK_HUMAN (1-509): 0: 661: 100.00		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		411573 LCK_HUMAN (1-509): 0: 661: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		411553 LCK_HUMAN (1-509): 0: 661: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		411552 LCK_HUMAN (1-509): 0: 661: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		411545 LCK_HUMAN (1-509): 0: 661: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		411559 LCK_HUMAN (1-509): 0: 661: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		411544 LCK_HUMAN (1-509): 0: 661: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		442772 HCK_HUMAN (1-509): 0: 602: 65.04		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433530 HCK_HUMAN (1-509): 0: 602: 65.04		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Mm
		536205 FGR_MOUSE (1-507): 0: 591: 53.19		FGR_MOUSE (10-211): 1.59e-51: 181: 17.49
+	Hs
		442759 HCK_HUMAN (1-509): 0: 602: 65.04		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Rn
		989767 LYN_RAT (1-509): 0: 590: 62.33		SRC_RAT (5-280): 5.38e-50: 177: 17.45
+	Rn
		989763 LYN_RAT (1-509): 0: 590: 62.33		LYN_RAT (9-284): 7.16e-47: 168: 14.58
+	Mm
		435875 HCK_MOUSE (1-509): 0: 590: 63.99		HCK_MOUSE (55-211): 3.68e-44: 161: 19.32
+	Hs
		411633 LCK_HUMAN (1-509): 0: 661: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		411632 LCK_HUMAN (1-509): 0: 661: 100.00		ZAP70_HUMAN (86-222): 1.53e-17: 86.1: 20.98
+	Mm
		411920 LCK_MOUSE (1-509): 0: 657: 96.86		ZAP70_MOUSE (94-193): 6.76e-15: 78.3: 24.53
+	Mm
		536207 FGR_MOUSE (1-507): 0: 591: 53.19		KSYK_MOUSE (95-213): 1.04e-17: 86.9: 25.60