HitPredict

Interactor 1: PLRG1 (O43660)
Pleiotropic regulator 1
Gene: PLRG1

Interactor 2: DHX35 (Q9H5Z1)
Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)
Gene: DHX35

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Hs			1 703
+	Hs
		209435 PLRG1_HUMAN (1-514): 1.02e-144: 427: 100.00		DHX8_HUMAN (34-701): 0: 970: 46.65
+	Zm
		18259 A0A1D6J4G2_MAIZE (191-514): 1.13e-89: 287: 17.61		A0A1D6H4I5_MAIZE (3-701): 0: 980: 45.83
+	Hs
		1288306 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		DHX35_HUMAN (1-703): 0: 1005: 100.00
+	Hs
		1055447 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		DHX8_HUMAN (34-701): 0: 970: 46.65
+	Hs
		1268349 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		PRP16_HUMAN (16-700): 0: 929: 41.92
+	Hs
		195578 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		DHX15_HUMAN (41-698): 0: 926: 44.05
+	Sc
		630874 NLE1_YEAST (200-514): 3.94e-86: 276: 20.98		PRP43_YEAST (15-701): 0: 885: 43.44
+	Hs
		224827 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		DHX16_HUMAN (27-701): 0: 932: 46.23
+	Hs
		1268324 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		PRP16_HUMAN (16-700): 0: 929: 41.92
+	Hs
		195393 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		DHX15_HUMAN (41-698): 0: 926: 44.05
+	Sc
		622354 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		PRP22_YEAST (7-700): 0: 916: 44.91
+	Hs
		224824 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		DHX16_HUMAN (27-701): 0: 932: 46.23
+	Sc
		859466 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		PRP43_YEAST (15-701): 0: 885: 43.44
+	Sc
		554258 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		PRP16_YEAST (41-688): 0: 831: 41.76
+	Hs
		994406 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		DHX9_HUMAN (1-701): 0: 789: 27.01
+	Sp
		142000 PRP46_SCHPO (10-439): 2.04e-69: 231: 19.27		YK99_SCHPO (32-687): 0: 763: 39.39
+	Sc
		589467 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		PRP2_YEAST (14-686): 0: 794: 37.66
+	Hs
		903167 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		DHX9_HUMAN (1-701): 0: 789: 27.01
+	Hs
		994278 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		DHX9_HUMAN (1-701): 0: 789: 27.01
+	Hs
		197089 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		DHX33_HUMAN (3-690): 0: 852: 41.88