HitPredict

Interactor 1: RGS10 (O43665)
Regulator of G-protein signaling 10 (RGS10)
Gene: RGS10

Interactor 2: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	8774883
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 354
+	Hs
		444692 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00
+	Hs
		207517 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79
+	Hs
		283183 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79
+	Hs
		391357 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92
+	Hs
		207507 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00
+	Hs
		444693 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00
+	Hs
		207505 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92
+	Hs
		283156 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92
+	Hs
		277782 RGS9_HUMAN (2-172): 1.77e-56: 189: 30.90		GNAO_HUMAN (1-354): 6.89e-171: 481: 71.27
+	Hs
		283160 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAO_HUMAN (1-354): 6.89e-171: 481: 71.27
+	Mm
		579646 RGS14_MOUSE (21-175): 1.23e-55: 185: 45.22		GNAO_MOUSE (1-354): 4.73e-168: 473: 70.70
+	Dm
		592744 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAI_DROME (1-354): 3.42e-164: 464: 76.90
+	Bt
		221230 RGS9_BOVIN (2-172): 4.58e-57: 187: 30.34		GNAT1_BOVIN (1-354): 2.11e-164: 464: 64.97
+	Dm
		558483 RGS_DROME (9-166): 4.56e-55: 189: 39.62		GNAO_DROME (1-354): 1.51e-161: 457: 69.01
+	Hs
		834946 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAQ_HUMAN (1-353): 1.65e-161: 457: 51.41
+	Hs
		670435 RGS3_HUMAN (11-165): 1.81e-58: 198: 37.50		GNA11_HUMAN (1-353): 1.31e-156: 445: 50.28
+	Hs
		207511 RGS14_HUMAN (21-175): 1.99e-56: 187: 45.86		GNA11_HUMAN (1-353): 1.31e-156: 445: 50.28
+	Hs
		580410 RGS7_HUMAN (2-174): 7.07e-57: 187: 28.65		GNAZ_HUMAN (1-353): 7.65e-156: 443: 67.23
+	Hs
		283162 RGS20_HUMAN (3-163): 2.35e-57: 186: 33.33		GNAZ_HUMAN (1-353): 7.65e-156: 443: 67.23
+	Hs
		170629 AXIN1_HUMAN (7-172): 6.4e-55: 187: 30.86		GNAS2_HUMAN (1-353): 1.44e-139: 403: 38.68