HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 349
+	Mm
		223246 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (1-349): 1.96e-89: 274: 100.00
+	Mm
		223255 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (1-349): 4.08e-80: 250: 72.21
+	Hs
		899923 LDB1_HUMAN (8-373): 0: 610: 76.84		ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00
+	Mm
		223263 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (3-316): 2.14e-59: 198: 25.82
+	Mm
		223247 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (16-348): 8.12e-58: 194: 28.37
+	Mm
		223249 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (16-349): 2.43e-57: 192: 27.35
+	Mm
		223262 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (3-304): 5.42e-57: 191: 26.57
+	Mm
		223254 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (17-135): 8.72e-51: 168: 39.34
+	Hs
		839771 LDB1_HUMAN (8-373): 0: 610: 76.84		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Hs
		822644 LDB1_HUMAN (8-373): 0: 610: 76.84		LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35
+	Hs
		210831 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Mm
		223248 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (17-132): 4e-25: 101: 40.34
+	Hs
		210838 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (17-134): 2.1e-24: 98.6: 38.84
+	Mm
		223259 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (4-74): 4.05e-14: 74.6: 21.13
+	Hs
		210841 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX4_HUMAN (4-73): 8.65e-14: 73.9: 26.76
+	Mm
		223245 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (4-73): 7.96e-14: 73.9: 26.76
+	Mm
		223242 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (4-74): 1.78e-13: 72.7: 19.72
+	Hs
		210834 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (5-77): 1.09e-09: 61.1: 21.92
+	Hs
		903745 LDB1_HUMAN (8-373): 0: 610: 76.84		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		238112 LDB1_HUMAN (8-373): 0: 610: 76.84		LMX1B_HUMAN (4-74): 2.12e-13: 72.7: 19.72