Interactor 1: CIKS (O43734)
E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
Gene: TRAF3IP2

Interactor 2: I17RA (Q96F46)
Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)
Gene: IL17RA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 28219902, 25202827, 24120361, 32350852, 17277779, 17035243
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SEFIR~SEFIR
Common GO terms GO:0005102 - signaling receptor binding
GO:0006954 - inflammatory response
GO:0038173 - interleukin-17A-mediated signaling pathway
GO:0072538 - T-helper 17 type immune response
GO:0097400 - interleukin-17-mediated signaling pathway
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 574
Hs

1 866
+ Mm
+ Hs

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Last updated: 15 Jul 2024