HitPredict

Interactor 1: AP1G1 (O43747)
AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)
Gene: AP1G1

Interactor 2: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	18524853, 15758025
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005905 - clathrin-coated pit GO:0016020 - membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 896
+	Hs
		321504 AP2A1_HUMAN (3-808): 0: 594: 24.39		EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00
+	Hs
		302112 AP2A2_HUMAN (3-813): 0: 582: 24.55		EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00
+	Hs
		787890 AP2B1_HUMAN (30-800): 0: 552: 16.59		EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00
+	Mm
		567515 AP2A2_MOUSE (3-808): 0: 585: 24.70		EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54
+	Rn
		88764 D3ZUY8_RAT (3-808): 0: 594: 24.68		Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79
+	Mm
		788007 AP2B1_MOUSE (30-800): 0: 552: 16.59		EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54
+	Rn
		1126749 Q66HM2_RAT (3-808): 0: 584: 24.67		Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79
+	Rn
		923853 AP2B1_RAT (30-800): 0: 552: 16.59		Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79
+	Hs
		926031 AP2B1_HUMAN (30-800): 0: 552: 16.59		ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40
+	Hs
		321552 AP2A1_HUMAN (3-808): 0: 594: 24.39		ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61
+	Hs
		302157 AP2A2_HUMAN (3-813): 0: 582: 24.55		ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61
+	Rn
		88768 D3ZUY8_RAT (3-808): 0: 594: 24.68		ITSN1_RAT (11-737): 4.81e-34: 143: 12.14
+	Hs
		925876 AP2B1_HUMAN (30-800): 0: 552: 16.59		ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61
+	Hs
		925895 AP2B1_HUMAN (30-800): 0: 552: 16.59		FKB15_HUMAN (76-873): 1.31e-37: 154: 11.35
+	Rn
		923861 AP2B1_RAT (30-800): 0: 552: 16.59		ITSN1_RAT (11-737): 4.81e-34: 143: 12.14
+	Dm
		91156 AP2A_DROME (3-807): 0: 562: 22.73		E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27
+	Hs
		321640 AP2A1_HUMAN (3-808): 0: 594: 24.39		EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72
+	Ce
		1094946 Q22601_CAEEL (3-817): 0: 564: 23.75		Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85
+	Hs
		321661 AP2A1_HUMAN (3-808): 0: 594: 24.39		EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98
+	Hs
		302221 AP2A2_HUMAN (3-813): 0: 582: 24.55		EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98