Interactor 1: EMC8 (O43402)
ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)
Gene: EMC8
Interactor 2: EMC2 (Q15006)
ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)
Gene: EMC2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.989 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22119785, 30021884, 35271311, 37071682, 35575683, 38334954, 39358380, 31839598, 25416956, 26186194, 16189514, 26496610, 28514442, 32296183, 27342126, 33961781, 35235311, 34349018, 40437099, unassigned1304 and 1 others
more... |
| Identification Methods | affinity chromatography technology, proximity labelling technology, cross-linking study, two hybrid, validated two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, two hybrid pooling approach |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | TPR_EMC2~UPF0172 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0045050 - protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0071816 - tail-anchored membrane protein insertion into ER membrane and 1 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
