Protein: MED25
Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)

Gene: MED25
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q71SY5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001223 - transcription coactivator binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1174978

MED23
Mediator of RNA polymerase II transcription subunit 23

5

1

Small-scale

0.922

High

1174979

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

Small-scale

0.836

High

826303

CDK8
Cyclin-dependent kinase 8

10

2

Small-scale

0.751

High

1076172

MED1
Mediator of RNA polymerase II transcription subunit 1

8

3

Small-scale

0.744

High

48690

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.718

High

1174958

MED10
Mediator of RNA polymerase II transcription subunit 10

5

1

Small-scale

0.716

High

1174949

MED12
Mediator of RNA polymerase II transcription subunit 12

4

2

Small-scale

0.694

High

369878

ESR1
Estrogen receptor

4

8

Small-scale

0.688

High

225394

MED14
Mediator of RNA polymerase II transcription subunit 14

4

5

Small-scale

0.683

High

270514

MED6
Mediator of RNA polymerase II transcription subunit 6

4

1

Small-scale

0.672

High

1174962

MED28
Mediator of RNA polymerase II transcription subunit 28

4

0

High-throughput

0.664

High

265341

MED24
Mediator of RNA polymerase II transcription subunit 24

4

0

Small-scale

0.661

High

1174967

MED4
Mediator of RNA polymerase II transcription subunit 4

3

0

High-throughput

0.646

High

1174970

MED29
Mediator of RNA polymerase II transcription subunit 29

3

0

High-throughput

0.646

High

1174954

MED15
Mediator of RNA polymerase II transcription subunit 15

3

3

Small-scale

0.640

High

313443

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

Small-scale

0.638

High

624458

CCNC
Cyclin-C

3

0

High-throughput

0.638

High

1037067

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.638

High

1174969

MED9
Mediator of RNA polymerase II transcription subunit 9

3

0

Small-scale

0.634

High

1174961

CDK19
Cyclin-dependent kinase 19

2

2

High-throughput

0.628

High

1174968

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

Small-scale

0.611

High

118571

EYA2
Eyes absent homolog 2

2

1

High-throughput

0.606

High

125535

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

1

High-throughput

0.606

High

738974

SRBP1
Sterol regulatory element-binding protein 1

2

4

Small-scale

0.595

High

587185

RXRA
Retinoic acid receptor RXR-alpha

1

7

Small-scale

0.594

High

206630

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

Small-scale

0.585

High

1174959

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

High-throughput

0.585

High

49911

ODAM
Odontogenic ameloblast-associated protein

2

0

High-throughput

0.580

High

849899

STA5B
Signal transducer and activator of transcription 5B

2

0

High-throughput

0.580

High

993476

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1157129

ESRP1
Epithelial splicing regulatory protein 1

2

0

High-throughput

0.580

High

1174960

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1174971

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1174972

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.580

High

1174977

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

1174976

MED13
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.576

High

487987

RARA
Retinoic acid receptor alpha

1

8

Small-scale

0.573

High

244594

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

1174955

FEZ1
Fasciculation and elongation protein zeta-1

2

1

High-throughput

0.558

High

160055

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

1

High-throughput

0.553

High

1174944

OXER1
Oxoeicosanoid receptor 1

2

1

High-throughput

0.553

High

1174946

TFG
Protein TFG

2

1

High-throughput

0.553

High

1174948

CBP
CREB-binding protein

1

1

Small-scale

0.552

High

1069393

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1174947

RORB
Nuclear receptor ROR-beta

1

5

High-throughput

0.515

High

426675

H10
Histone H1.0

1

0

High-throughput

0.513

High

509035

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

624944

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.513

High

804275

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

897547

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

989330

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

1074710

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.513

High

1087215

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1158898

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.513

High

1174950

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.513

High

1174952

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

1174957

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.513

High

1174966

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1174973

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

1174974

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

1174980

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

377423

GCR
Glucocorticoid receptor

1

8

Small-scale

0.508

High

337493

ABL1
Tyrosine-protein kinase ABL1

1

1

Small-scale

0.501

High

500436

THA
Thyroid hormone receptor alpha

1

7

Small-scale

0.481

High

1123349

Q58EY0
RAR related orphan receptor B isoform 1

1

6

High-throughput

0.481

High

1174982

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

266375

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

1078575

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1078723

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1132704

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

1

High-throughput

0.479

High

1174943

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

Small-scale

0.479

High

1174945

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1174964

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.460

High

1018999

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1076250

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1174953

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1174956

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1174965

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

411777

LCK
Tyrosine-protein kinase Lck

1

1

Small-scale

0.457

High

500494

THB
Thyroid hormone receptor beta

1

7

Small-scale

0.457

High

1174963

Q9H2M2
Estrogen receptor 1

1

1

Small-scale

0.457

High

123993

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.445

High

1174981

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

49957

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

67171

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1060000

LASP1
LIM and SH3 domain protein 1

2

0

High-throughput

0.316

High

1109124

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.316

High

1120772

KLH12
Kelch-like protein 12

2

0

High-throughput

0.316

High

1174038

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1174951

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

1174975

PEF1
Peflin

2

0

High-throughput

0.316

High

1109312

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024