HitPredict

Interactor 1: ORC5 (O43913)
Origin recognition complex subunit 5
Gene: ORC5

Interactor 2: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	12614612
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	MCM_lid~ORC5_C
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 863
+	Hs
		217242 ORC5_HUMAN (1-435): 8.6e-159: 457: 100.00		MCM2_HUMAN (2-839): 0: 762: 27.95
+	Hs
		708434 ORC1_HUMAN (1-307): 9.45e-80: 265: 12.42		MCM4_HUMAN (1-863): 0: 952: 100.00
+	Hs
		217235 ORC5_HUMAN (1-435): 8.6e-159: 457: 100.00		MCM5_HUMAN (133-846): 0: 698: 30.23
+	Hs
		217236 ORC5_HUMAN (1-435): 8.6e-159: 457: 100.00		MCM7_HUMAN (158-841): 0: 660: 29.88
+	Hs
		217779 ORC4_HUMAN (6-286): 1.48e-36: 140: 14.65		MCM4_HUMAN (1-863): 0: 952: 100.00
+	Hs
		832668 CDC6_HUMAN (2-318): 3.42e-89: 283: 13.37		MCM2_HUMAN (2-839): 0: 762: 27.95
+	Hs
		832428 ORC1_HUMAN (1-307): 9.45e-80: 265: 12.42		MCM2_HUMAN (2-839): 0: 762: 27.95
+	Hs
		708744 CDC6_HUMAN (2-318): 3.42e-89: 283: 13.37		MCM5_HUMAN (133-846): 0: 698: 30.23
+	Hs
		708627 ORC1_HUMAN (1-307): 9.45e-80: 265: 12.42		MCM5_HUMAN (133-846): 0: 698: 30.23
+	Sc
		667602 ORC5_YEAST (6-433): 1.29e-86: 273: 21.52		MCM2_YEAST (4-784): 0: 688: 26.05
+	Sc
		667870 ORC5_YEAST (6-433): 1.29e-86: 273: 21.52		MCM5_YEAST (156-840): 0: 688: 30.08
+	Hs
		1306121 CDC6_HUMAN (2-318): 3.42e-89: 283: 13.37		MCM8_HUMAN (94-863): 0: 663: 24.76
+	Hs
		709020 CDC6_HUMAN (2-318): 3.42e-89: 283: 13.37		MCM7_HUMAN (158-841): 0: 660: 29.88
+	Hs
		1033381 ORC1_HUMAN (1-307): 9.45e-80: 265: 12.42		MCM6_HUMAN (138-842): 0: 675: 26.97
+	Sc
		675544 ORC1_YEAST (8-238): 7.5e-51: 186: 12.37		MCM4_YEAST (1-862): 0: 745: 41.83
+	Hs
		708888 ORC1_HUMAN (1-307): 9.45e-80: 265: 12.42		MCM7_HUMAN (158-841): 0: 660: 29.88
+	Sc
		447785 CDC6_YEAST (1-327): 9.31e-57: 196: 11.72		MCM2_YEAST (4-784): 0: 688: 26.05
+	Sc
		447786 CDC6_YEAST (1-327): 9.31e-57: 196: 11.72		MCM5_YEAST (156-840): 0: 688: 30.08
+	Sc
		667613 ORC1_YEAST (8-238): 7.5e-51: 186: 12.37		MCM2_YEAST (4-784): 0: 688: 26.05
+	Sc
		667877 ORC1_YEAST (8-238): 7.5e-51: 186: 12.37		MCM5_YEAST (156-840): 0: 688: 30.08