Protein: AK1C1
Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB)

Gene: AK1C1, AKR1C1
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q04828

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0004032 - aldose reductase (NADPH) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838908

AK1C3
Aldo-keto reductase family 1 member C3

5

11

High-throughput

0.922

High

915021

AK1C2
Aldo-keto reductase family 1 member C2

5

11

High-throughput

0.919

High

908340

AK1D1
Aldo-keto reductase family 1 member D1

3

11

High-throughput

0.848

High

683991

PTN3
Tyrosine-protein phosphatase non-receptor type 3

3

0

High-throughput

0.646

High

605037

AK1C4
Aldo-keto reductase family 1 member C4

1

11

High-throughput

0.618

High

353272

AGR2
Anterior gradient protein 2 homolog

2

3

Small-scale

0.533

High

389311

FINC
Fibronectin

1

0

High-throughput

0.513

High

691714

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.508

High

1048468

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1048470

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.489

High

1048474

COMD8
COMM domain-containing protein 8

1

0

High-throughput

0.486

High

400690

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

934502

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.479

High

1026328

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1048473

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

1048475

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

623295

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

1048472

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

135920

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.445

High

529675

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

1048471

TMM59
Transmembrane protein 59

1

2

High-throughput

0.445

High

259834

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

261159

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.407

High

605001

HXB6
Homeobox protein Hox-B6

1

2

High-throughput

0.407

High

1048466

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1048465

TFF3
Trefoil factor 3

1

0

Small-scale

0.288

High

1048476

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1030153

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.232

Low

1048467

AVPI1
Arginine vasopressin-induced protein 1

1

0

High-throughput

0.232

Low

1048469

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025