HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20085707
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001673 - male germ cell nucleus GO:0005634 - nucleus GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 143
+	Hs
		217498 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25
+	Mm
		83337 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		H2A1B_MOUSE (1-129): 8.35e-66: 197: 90.70
+	Hs
		299035 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		299027 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		299030 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47
+	Hs
		299066 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A2A_HUMAN (1-129): 7e-66: 197: 91.47
+	Hs
		260689 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		555582 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		555466 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		260757 SP100_HUMAN (3-296): 1.81e-36: 146: 13.81		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		555610 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		1059717 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97
+	Hs
		1059795 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19
+	Hs
		391704 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		470387 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47
+	Hs
		1059647 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70
+	Hs
		260883 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		260982 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		391675 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Sc
		392566 RCO1_YEAST (143-476): 9.27e-35: 140: 14.89		H2A2_YEAST (16-124): 4.61e-53: 165: 82.57