Protein: E41L2
Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)

Gene: E41L2, EPB41L2
Organism: Homo sapiens
Interactions: 220
UniProt ID: O43491

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005198 - structural molecule activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

217545

E41L3
Band 4.1-like protein 3

4

15

High-throughput

0.903

High

217361

RASK
GTPase KRas

4

20

High-throughput

0.873

High

217522

E41L1
Band 4.1-like protein 1

2

16

High-throughput

0.811

High

217359

RASN
GTPase NRas

2

20

High-throughput

0.754

High

217417

1433G
14-3-3 protein gamma

5

20

High-throughput

0.725

High

217356

DDAH2
Putative hydrolase DDAH2

4

4

High-throughput

0.691

High

217410

ICLN
Methylosome subunit pICln

3

6

High-throughput

0.675

High

217422

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.658

High

175813

SET1A
Histone-lysine N-methyltransferase SETD1A

2

11

High-throughput

0.628

High

217354

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

2

1

High-throughput

0.628

High

217373

POTEI
POTE ankyrin domain family member I

2

5

High-throughput

0.628

High

217401

AF9
Protein AF-9

2

13

High-throughput

0.628

High

217408

CLK2
Dual specificity protein kinase CLK2

2

5

High-throughput

0.628

High

217425

ENL
Protein ENL

2

14

High-throughput

0.628

High

217436

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

4

High-throughput

0.628

High

217447

RNPS1
RNA-binding protein with serine-rich domain 1

2

10

High-throughput

0.628

High

217462

WDR59
GATOR2 complex protein WDR59

2

4

High-throughput

0.628

High

217475

KIBRA
Protein KIBRA

2

17

High-throughput

0.628

High

217519

PININ
Pinin

2

4

High-throughput

0.628

High

217527

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

7

High-throughput

0.628

High

217539

SRP68
Signal recognition particle subunit SRP68

2

1

High-throughput

0.628

High

217541

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

18

High-throughput

0.628

High

217544

SRRM2
Serine/arginine repetitive matrix protein 2

2

18

High-throughput

0.628

High

217387

1433T
14-3-3 protein theta

2

20

High-throughput

0.628

High

217394

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.621

High

217442

NUMA1
Nuclear mitotic apparatus protein 1

2

14

Small-scale

0.619

High

217355

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.618

High

217357

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

217360

RASH
GTPase HRas

1

20

High-throughput

0.618

High

217371

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

217389

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

217392

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

217415

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.618

High

217420

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

217446

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

217542

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

217370

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.602

High

217343

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

217404

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

217419

ARF6
ADP-ribosylation factor 6

2

6

High-throughput

0.584

High

126025

AP3B1
AP-3 complex subunit beta-1

2

5

High-throughput

0.574

High

217510

CP2S1
Cytochrome P450 2S1

2

2

High-throughput

0.574

High

217540

GPTC8
G patch domain-containing protein 8

2

14

High-throughput

0.574

High

217362

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

217375

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

1

High-throughput

0.571

High

217434

GRM1
Metabotropic glutamate receptor 1

1

1

Small-scale

0.561

High

217418

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.554

High

217428

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

217400

GRIA1
Glutamate receptor 1

1

12

Small-scale

0.552

High

217368

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.541

High

64647

FA83G
Protein FAM83G

1

2

High-throughput

0.536

High

167671

LIN7A
Protein lin-7 homolog A

1

12

High-throughput

0.536

High

217346

CCNT1
Cyclin-T1

1

2

High-throughput

0.536

High

217348

SRS10
Serine/arginine-rich splicing factor 10

1

1

High-throughput

0.536

High

217381

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.536

High

217403

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

217406

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.536

High

217423

SRPK2
SRSF protein kinase 2

1

16

High-throughput

0.536

High

217458

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.536

High

217470

PIM3
Serine/threonine-protein kinase pim-3

1

10

High-throughput

0.536

High

217476

KT222
Keratin-like protein KRT222

1

5

High-throughput

0.536

High

217481

NKAP
NF-kappa-B-activating protein

1

3

High-throughput

0.536

High

217482

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.536

High

217486

CAMKV
CaM kinase-like vesicle-associated protein

1

5

High-throughput

0.536

High

217493

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.536

High

217498

FAN
Protein FAN

1

5

High-throughput

0.536

High

217546

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

High-throughput

0.536

High

104890

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

217525

WDR76
WD repeat-containing protein 76

2

5

High-throughput

0.533

High

217386

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

Small-scale

0.523

High

217341

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.515

High

217351

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

4

High-throughput

0.515

High

217378

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

3

Small-scale

0.515

High

217395

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

217502

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.515

High

217349

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

217385

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.513

High

217441

ARI5B
AT-rich interactive domain-containing protein 5B

1

0

High-throughput

0.493

High

217460

CXB7
Gap junction beta-7 protein

1

9

High-throughput

0.489

High

217471

ZCH18
Zinc finger CCCH domain-containing protein 18

1

14

High-throughput

0.489

High

217491

TBCK
TBC domain-containing protein kinase-like protein

1

11

High-throughput

0.489

High

217504

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

217506

KLH15
Kelch-like protein 15

1

4

High-throughput

0.489

High

217515

NUAK2
NUAK family SNF1-like kinase 2

1

7

High-throughput

0.489

High

217531

KLC4
Kinesin light chain 4

1

2

High-throughput

0.489

High

217372

ATX1L
Ataxin-1-like

1

1

High-throughput

0.481

High

125089

LEG9
Galectin-9

1

4

High-throughput

0.479

High

189326

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

217342

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

217344

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.479

High

217345

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

217347

PR40A
Pre-mRNA-processing factor 40 homolog A

1

13

High-throughput

0.479

High

217350

FLOT1
Flotillin-1

1

9

High-throughput

0.479

High

217358

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

217363

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

217365

GCR
Glucocorticoid receptor

1

19

High-throughput

0.479

High

217367

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

217369

H2A1B
Histone H2A type 1-B/E

1

3

High-throughput

0.479

High

217376

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.479

High

217377

LAMP1
Lysosome-associated membrane glycoprotein 1

1

7

High-throughput

0.479

High

217379

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

217380

CXA1
Gap junction alpha-1 protein

1

9

High-throughput

0.479

High

217383

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

High-throughput

0.479

High

217384

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.479

High

217388

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

217390

PML
Protein PML

1

11

High-throughput

0.479

High

217391

MARCS
Myristoylated alanine-rich C-kinase substrate

1

11

High-throughput

0.479

High

217393

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.479

High

217396

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

217397

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

217398

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

7

High-throughput

0.479

High

217399

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

217402

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.479

High

217405

KC1D
Casein kinase I isoform delta

1

2

High-throughput

0.479

High

217407

RBM25
RNA-binding protein 25

1

7

High-throughput

0.479

High

217409

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

217411

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

217412

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

217413

ARL4C
ADP-ribosylation factor-like protein 4C

1

19

High-throughput

0.479

High

217416

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.479

High

217426

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

217427

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

217429

UBE3A
Ubiquitin-protein ligase E3A

1

10

High-throughput

0.479

High

217432

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

13

High-throughput

0.479

High

217433

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

217435

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

217437

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

217438

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

2

High-throughput

0.479

High

217439

SRC8
Src substrate cortactin

1

12

High-throughput

0.479

High

217440

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.479

High

217443

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

4

High-throughput

0.479

High

217444

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

217445

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

217449

OCLN
Occludin

1

10

High-throughput

0.479

High

217450

AR13B
ADP-ribosylation factor-like protein 13B

1

12

High-throughput

0.479

High

217451

MIDN
Midnolin

1

5

High-throughput

0.479

High

217454

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

217456

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

217459

TAF2
Transcription initiation factor TFIID subunit 2

1

2

High-throughput

0.479

High

217461

RHDF2
Inactive rhomboid protein 2

1

5

High-throughput

0.479

High

217463

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

217464

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

217469

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

217472

TAXB1
Tax1-binding protein 1

1

11

High-throughput

0.479

High

217479

ARL14
ADP-ribosylation factor-like protein 14

1

12

High-throughput

0.479

High

217483

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.479

High

217485

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

217487

RB15B
Putative RNA-binding protein 15B

1

3

High-throughput

0.479

High

217489

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

217494

ATX2L
Ataxin-2-like protein

1

9

High-throughput

0.479

High

217495

ASB11
Ankyrin repeat and SOCS box protein 11

1

20

High-throughput

0.479

High

217496

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.479

High

217497

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

217499

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

217501

CK052
Uncharacterized protein C11orf52

1

8

High-throughput

0.479

High

217503

SPDLY
Protein Spindly

1

7

High-throughput

0.479

High

217507

FMNL2
Formin-like protein 2

1

6

High-throughput

0.479

High

217509

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

217514

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

217517

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.479

High

217520

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.479

High

217523

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

217524

BRD9
Bromodomain-containing protein 9

1

3

High-throughput

0.479

High

217526

MOV10
Helicase MOV-10

1

1

High-throughput

0.479

High

217528

ANLN
Anillin

1

5

High-throughput

0.479

High

217529

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

217532

DCA13
DDB1- and CUL4-associated factor 13

1

5

High-throughput

0.479

High

217533

ARL15
ADP-ribosylation factor-like protein 15

1

14

High-throughput

0.479

High

217534

DDX56
Probable ATP-dependent RNA helicase DDX56

1

3

High-throughput

0.479

High

217536

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.479

High

217537

ABCF2
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.479

High

217538

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

217543

TRI33
E3 ubiquitin-protein ligase TRIM33

1

10

High-throughput

0.479

High

129616

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.458

High

154450

CLD4
Claudin-4

1

0

Small-scale

0.458

High

217364

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

217421

H4
Histone H4

1

0

High-throughput

0.458

High

217431

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

217468

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

217474

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

217488

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

217490

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

Small-scale

0.458

High

217508

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

217512

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

217516

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

217518

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

217530

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

217535

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

217430

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.457

High

217521

WNK1
Serine/threonine-protein kinase WNK1

1

7

High-throughput

0.457

High

217366

PRIO
Major prion protein

1

3

High-throughput

0.445

High

217374

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

217453

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

217457

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

217473

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

217477

LAT4
Large neutral amino acids transporter small subunit 4

1

5

High-throughput

0.445

High

217480

CTL3
Choline transporter-like protein 3

1

4

High-throughput

0.445

High

217505

S45A3
Solute carrier family 45 member 3

1

2

High-throughput

0.445

High

139772

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

217352

TOX4
TOX high mobility group box family member 4

1

2

High-throughput

0.437

High

217353

ZFPL1
Zinc finger protein-like 1

1

6

High-throughput

0.437

High

217382

HXA5
Homeobox protein Hox-A5

1

1

High-throughput

0.437

High

217424

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

217455

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

217465

MOB3C
MOB kinase activator 3C

1

7

High-throughput

0.437

High

217467

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

217492

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.437

High

217511

SEC62
Translocation protein SEC62

1

3

High-throughput

0.437

High

217513

MMTA2
Multiple myeloma tumor-associated protein 2

1

2

High-throughput

0.437

High

217547

ARL5A
ADP-ribosylation factor-like protein 5A

1

7

High-throughput

0.437

High

217448

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

217478

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

217500

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.426

High

62421

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

217484

S35G3
Solute carrier family 35 member G3

1

1

High-throughput

0.407

High

217414

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.279

Low

76466

ZN736
Zinc finger protein 736

1

0

High-throughput

0.269

Low

217452

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low

217466

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

217548

CCD61
Centrosomal protein CCDC61

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025