HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27365398
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 414
+	Hs
		217429 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Mm
		665773 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		PABP1_MOUSE (2-382): 8.56e-31: 126: 15.95
+	Hs
		162050 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		852058 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		201655 SP100_HUMAN (3-296): 1.81e-36: 146: 13.81		MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93
+	Hs
		162028 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		852032 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		170175 TIF1A_HUMAN (421-491): 1.58e-13: 75.6: 29.58		MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93
+	Hs
		1031332 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		1018458 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		516522 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516483 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		617298 SP100_HUMAN (3-296): 1.81e-36: 146: 13.81		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		1048064 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		1018471 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516745 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Sc
		376840 JHD2_YEAST (287-341): 3.21e-10: 64.7: 43.10		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Hs
		516645 NSD1_HUMAN (285-383): 1.69e-11: 69.4: 30.69		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Sc
		812514 JHD2_YEAST (287-341): 3.21e-10: 64.7: 43.10		HRP1_YEAST (101-289): 6.38e-20: 93.6: 31.50