Protein: TRIB3
Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)

Gene: TRIB3
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q96RU7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0004860 - protein kinase inhibitor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1231635

STK40
Serine/threonine-protein kinase 40

4

20

High-throughput

0.903

High

681990

AKT1
RAC-alpha serine/threonine-protein kinase

3

17

Small-scale

0.880

High

781422

BCL6
B-cell lymphoma 6 protein

3

3

Small-scale

0.858

High

1036829

SQSTM
Sequestosome-1

2

7

Small-scale

0.806

High

171325

EPHB6
Ephrin type-B receptor 6

2

6

High-throughput

0.783

High

212493

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

14

High-throughput

0.783

High

855181

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

6

High-throughput

0.783

High

1144756

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

4

High-throughput

0.783

High

1243027

GLIS3
Zinc finger protein GLIS3

2

5

High-throughput

0.783

High

1251767

ZN417
Zinc finger protein 417

2

2

High-throughput

0.783

High

1301545

ZN587
Zinc finger protein 587

2

1

High-throughput

0.783

High

1301554

PAR6B
Partitioning defective 6 homolog beta

2

3

High-throughput

0.783

High

579283

ATF4
Cyclic AMP-dependent transcription factor ATF-4

8

2

Small-scale

0.758

High

835957

GSK3B
Glycogen synthase kinase-3 beta

2

20

Small-scale

0.754

High

1246149

COP1
E3 ubiquitin-protein ligase COP1

7

11

Small-scale

0.748

High

204417

MS18B
Protein Mis18-beta

2

0

High-throughput

0.742

High

1301568

TCF19
Transcription factor 19

2

0

High-throughput

0.742

High

1046385

BMPR2
Bone morphogenetic protein receptor type-2

1

2

Small-scale

0.740

High

566460

KPCA
Protein kinase C alpha type

1

17

Small-scale

0.724

High

363270

FINC
Fibronectin

1

1

Small-scale

0.713

High

1301571

GIT1
ARF GTPase-activating protein GIT1

1

9

High-throughput

0.698

High

1301562

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

4

3

Small-scale

0.697

High

549130

ZNF44
Zinc finger protein 44

1

1

High-throughput

0.691

High

1082344

DDB1
DNA damage-binding protein 1

1

5

High-throughput

0.691

High

1215925

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

17

High-throughput

0.691

High

1218230

MAPK5
MAP kinase-activated protein kinase 5

1

20

High-throughput

0.691

High

931808

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.676

High

1260450

UBTD2
Ubiquitin domain-containing protein 2

2

0

High-throughput

0.655

High

488017

RARA
Retinoic acid receptor alpha

2

14

Small-scale

0.624

High

1301551

RBM4
RNA-binding protein 4

1

7

Small-scale

0.621

High

153159

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

16

Small-scale

0.618

High

338871

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

673431

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.618

High

682202

AKT2
RAC-beta serine/threonine-protein kinase

1

16

Small-scale

0.618

High

891986

ACTB
Actin, cytoplasmic 1

1

6

Small-scale

0.618

High

972241

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

19

Small-scale

0.618

High

1301544

TRIB3
Tribbles homolog 3

1

14

Small-scale

0.618

High

1301561

SNRK
SNF-related serine/threonine-protein kinase

1

18

Small-scale

0.618

High

1301569

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

9

Small-scale

0.614

High

324569

BAG3
BAG family molecular chaperone regulator 3

2

2

High-throughput

0.606

High

447284

HXB5
Homeobox protein Hox-B5

2

5

High-throughput

0.606

High

638380

RBTN2
Rhombotin-2

2

6

High-throughput

0.606

High

678965

HXC8
Homeobox protein Hox-C8

2

4

High-throughput

0.606

High

850446

CLCKA
Chloride channel protein ClC-Ka

2

3

High-throughput

0.606

High

880808

HDAC4
Histone deacetylase 4

2

10

High-throughput

0.606

High

924805

GRB2
Growth factor receptor-bound protein 2

2

14

High-throughput

0.606

High

1024506

CAF1A
Chromatin assembly factor 1 subunit A

2

1

High-throughput

0.606

High

1037532

BFSP2
Phakinin

2

4

High-throughput

0.606

High

1047702

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

10

High-throughput

0.606

High

1189689

K1C26
Keratin, type I cytoskeletal 26

2

4

High-throughput

0.606

High

1200322

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

2

High-throughput

0.606

High

1251440

LMO3
LIM domain only protein 3

2

5

High-throughput

0.606

High

1262187

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1296283

PKNX2
Homeobox protein PKNOX2

2

1

High-throughput

0.606

High

1298907

SAM11
Sterile alpha motif domain-containing protein 11

2

1

High-throughput

0.606

High

1301546

PITX2
Pituitary homeobox 2

2

5

High-throughput

0.606

High

1301553

TEKT3
Tektin-3

2

1

High-throughput

0.606

High

1301558

CBX8
Chromobox protein homolog 8

2

2

High-throughput

0.606

High

1301566

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.606

High

1301570

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

13

High-throughput

0.606

High

727181

DDIT3
DNA damage-inducible transcript 3 protein

2

0

Small-scale

0.598

High

1296298

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

2

10

High-throughput

0.597

High

63521

PRR19
Proline-rich protein 19

2

0

High-throughput

0.580

High

158844

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.580

High

448787

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

943943

IRX6
Iroquois-class homeodomain protein IRX-6

2

0

High-throughput

0.580

High

993563

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1012316

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1157488

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.580

High

1167235

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.580

High

1217884

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.580

High

1286101

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.580

High

1301549

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1301552

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1301556

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1301560

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.580

High

1301563

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.580

High

1301564

GPT2L
G patch domain-containing protein 2-like

2

0

High-throughput

0.580

High

1301565

SPG21
Maspardin

2

0

High-throughput

0.580

High

1301567

PADI4
Protein-arginine deiminase type-4

2

0

High-throughput

0.580

High

153761

ANM5
Protein arginine N-methyltransferase 5

1

4

High-throughput

0.573

High

347655

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.561

High

668921

PML
Protein PML

1

5

Small-scale

0.561

High

1076857

TWST1
Twist-related protein 1

1

2

Small-scale

0.561

High

1272153

OSTF1
Osteoclast-stimulating factor 1

1

7

High-throughput

0.555

High

328038

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

3

High-throughput

0.553

High

942551

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.553

High

1103525

KLH38
Kelch-like protein 38

2

4

High-throughput

0.553

High

1271391

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

3

High-throughput

0.553

High

231327

GANP
Germinal-center associated nuclear protein

1

1

Small-scale

0.552

High

1216688

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.552

High

1301559

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

14

Small-scale

0.552

High

1301547

MDFI
MyoD family inhibitor

1

0

High-throughput

0.549

High

644135

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.541

High

1065694

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.541

High

1184949

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.541

High

1273452

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.541

High

573430

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

770993

TCPZ
T-complex protein 1 subunit zeta

1

13

High-throughput

0.536

High

821371

TCPE
T-complex protein 1 subunit epsilon

1

15

High-throughput

0.536

High

826833

TCPG
T-complex protein 1 subunit gamma

1

12

High-throughput

0.536

High

843001

TCPQ
T-complex protein 1 subunit theta

1

18

High-throughput

0.536

High

843343

TCPD
T-complex protein 1 subunit delta

1

13

High-throughput

0.536

High

1061046

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.536

High

1185080

DET1
DET1 homolog

1

3

High-throughput

0.536

High

1301548

TCPH
T-complex protein 1 subunit eta

1

14

High-throughput

0.536

High

1191536

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

4

High-throughput

0.534

High

313675

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

Small-scale

0.529

High

660677

GRN
Progranulin

1

0

Small-scale

0.529

High

1130087

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

867247

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

1231799

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

1

Small-scale

0.504

High

395546

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

682545

ABC3A
DNA dC->dU-editing enzyme APOBEC-3A

1

3

Small-scale

0.501

High

1024077

ACACA
Acetyl-CoA carboxylase 1

1

8

Small-scale

0.501

High

1301572

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

233953

GDF9
Growth/differentiation factor 9

1

1

High-throughput

0.494

High

224644

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.489

High

1301574

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

2

High-throughput

0.489

High

1301575

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.489

High

445498

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.481

High

637986

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.481

High

1282018

TRI63
E3 ubiquitin-protein ligase TRIM63

1

12

High-throughput

0.481

High

1301555

TRI55
Tripartite motif-containing protein 55

1

12

High-throughput

0.481

High

380675

K2C1
Keratin, type II cytoskeletal 1

1

3

Small-scale

0.479

High

455777

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.479

High

487698

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

599716

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

Small-scale

0.479

High

717295

CTNB1
Catenin beta-1

1

3

Small-scale

0.479

High

724128

K1C9
Keratin, type I cytoskeletal 9

1

3

Small-scale

0.479

High

724974

MYH9
Myosin-9

1

7

Small-scale

0.479

High

725226

MYH10
Myosin-10

1

7

Small-scale

0.479

High

740585

PPARG
Peroxisome proliferator-activated receptor gamma

1

17

Small-scale

0.479

High

950256

SMAD3
Mothers against decapentaplegic homolog 3

1

11

Small-scale

0.479

High

978860

TF65
Transcription factor p65

1

6

Small-scale

0.479

High

992443

PPARA
Peroxisome proliferator-activated receptor alpha

1

15

Small-scale

0.479

High

1289402

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

Small-scale

0.479

High

1301573

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

103831

G5E9A7
DM1 locus, WD repeat containing

1

11

High-throughput

0.470

High

1012173

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

856164

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

Small-scale

0.460

High

885754

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

1239470

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.318

High

849807

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

1107931

F161A
Protein FAM161A

2

0

High-throughput

0.316

High

1135062

PPR26
Protein phosphatase 1 regulatory subunit 26

2

0

High-throughput

0.316

High

1140012

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1160227

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1191294

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

1205609

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1223776

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1301550

UTP23
rRNA-processing protein UTP23 homolog

2

0

High-throughput

0.316

High

1301557

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High


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Last updated: 15 Jul 2024