HitPredict

Interactor 1: PDE6D (O43924)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)
Gene: PDE6D

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.665

Property	Details
Experiments	11980706, 23698361, 23559067
Identification Methods	two hybrid, fluorescent resonance energy transfer, pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 184
+	Hs
		217712 PDE6D_HUMAN (1-150): 1.96e-98: 281: 100.00		RAB13_HUMAN (1-180): 8.32e-73: 219: 28.42
+	Hs
		217719 PDE6D_HUMAN (1-150): 1.96e-98: 281: 100.00		RAP1A_HUMAN (5-163): 2.2e-36: 126: 40.85
+	Hs
		217716 PDE6D_HUMAN (1-150): 1.96e-98: 281: 100.00		RAP2B_HUMAN (19-181): 1.59e-34: 121: 40.24