HitPredict

Interactor 1: SMD3 (O44437)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SMD3

Interactor 2: Q9VAX8 (Q9VAX8)
116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP-specific protein, 116 kDa)
Gene: DmelCG4849

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25294943
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	GTP_EFTU~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005682 - U5 snRNP GO:0005829 - cytosol GO:0030532 - small nuclear ribonucleoprotein complex GO:0071011 - precatalytic spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 151 Dm			1 975
+	Hs
		912641 SMD3_HUMAN (1-106): 4.39e-38: 127: 83.96		U5S1_HUMAN (1-975): 0: 1033: 74.87
+	Hs
		1064898 LSM4_HUMAN (5-135): 1.18e-36: 124: 29.20		U5S1_HUMAN (1-975): 0: 1033: 74.87
+	Hs
		912298 SMD1_HUMAN (7-95): 1.66e-34: 118: 23.60		U5S1_HUMAN (1-975): 0: 1033: 74.87
+	Hs
		1064875 LSM2_HUMAN (8-91): 2.95e-30: 106: 22.09		U5S1_HUMAN (1-975): 0: 1033: 74.87
+	Hs
		911839 RUXF_HUMAN (1-72): 3.05e-28: 101: 21.92		U5S1_HUMAN (1-975): 0: 1033: 74.87
+	Dm
		218354 SMD3_DROME (1-139): 1.15e-36: 125: 100.00		EF2_DROME (116-960): 0: 928: 36.62
+	Sp
		193901 SMD1_SCHPO (7-95): 6.59e-34: 116: 21.35		SN114_SCHPO (1-973): 0: 933: 53.35
+	Sp
		292972 SMD3_SCHPO (3-100): 6.18e-33: 113: 60.20		SN114_SCHPO (1-973): 0: 933: 53.35
+	Sc
		731734 SMD3_YEAST (4-100): 9.63e-33: 113: 42.27		SN114_YEAST (3-970): 0: 687: 32.53
+	Sc
		731722 LSM2_YEAST (8-90): 3.09e-28: 101: 16.47		SN114_YEAST (3-970): 0: 687: 32.53
+	Sc
		731729 LSM4_YEAST (5-100): 6.35e-27: 101: 20.56		SN114_YEAST (3-970): 0: 687: 32.53
+	Sc
		731758 SMD1_YEAST (7-115): 4.66e-27: 100: 22.06		SN114_YEAST (3-970): 0: 687: 32.53