HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: NHR80 (Q8ITW8)
Nuclear hormone receptor family member nhr-80
Gene: nhr-80

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22511885
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding GO:0008340 - determination of adult lifespan GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 504
+	Ce
		220357 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH121_CAEEL (23-463): 6.68e-105: 322: 33.63
+	Ce
		220334 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q20097_CAEEL (29-464): 2.33e-103: 317: 23.70
+	Ce
		109537 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR66_CAEEL (11-468): 1.25e-97: 312: 21.31
+	Ce
		220328 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR22_CAEEL (2-467): 3.43e-91: 291: 21.68
+	Ce
		220342 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR76_CAEEL (27-462): 4.94e-90: 285: 21.95
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (8-491): 6.17e-89: 283: 18.18
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (17-467): 6.52e-88: 278: 19.91
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (8-465): 2.7e-85: 273: 19.53
+	Ce
		220327 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR20_CAEEL (13-465): 1.23e-84: 270: 21.89
+	Ce
		220340 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR11_CAEEL (29-466): 3.39e-82: 264: 21.04
+	Ce
		220349 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR71_CAEEL (21-463): 1.38e-80: 263: 20.35
+	Ce
		219559 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O44577_CAEEL (26-466): 1.39e-80: 259: 21.75
+	Ce
		185183 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR79_CAEEL (27-466): 1.5e-78: 254: 20.39
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (7-463): 9.49e-79: 254: 18.44
+	Ce
		220352 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR13_CAEEL (41-476): 3.8e-77: 250: 23.98
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (17-335): 4.14e-77: 245: 21.12
+	Hs
		782501 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		NR2C2_HUMAN (17-467): 1.41e-93: 298: 16.53
+	Mm
		659675 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		VDR_MOUSE (10-466): 5.75e-76: 246: 15.55
+	Hs
		509917 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		VDR_HUMAN (10-466): 2.85e-74: 242: 15.55
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (27-120): 3.88e-13: 73.6: 40.43